From: Subject: ScienCentral: Smallpox Superbug? Date: Mon, 1 Sep 2003 08:03:39 +0300 MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_000_0000_01C3705F.8DA3C470"; type="text/html" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2800.1165 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01C3705F.8DA3C470 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciencentral.com/articles/view.php3?language=english&type=article&article_id=218392047 ScienCentral: Smallpox Superbug?
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  Immunization=20 Misinformation (09.05.00) - Most American kids = will have=20 had 20 or more vaccinations before they enter = kindergarten.=20 However, many parents are confused and concerned about = the=20 safety of vaccines. While vaccines seem like a good = idea, are=20 they really safe and necessary?=20

Yeast=20 Vaccine (07.25.01) - Researchers may have found a = vaccine=20 effective against the AIDS virus. =

  CDC: Smallpox Basics

Terrorism: Questions and Answers:=20 Smallpox


   08.29.03
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3Dsmallpox=20
image: ABC=20 news

When scientists reported in Nature Medicine that = the smallpox vaccine could last a = lifetime, it=20 sounded like good news for those concerned with = bioterrorism.

"It's fortunate, in terms of bioterrorism, that when it = comes to=20 smallpox, if it were to be used as a weapon of = bioterrorism=85 that we=20 already have a large number of people that have been = previously=20 vaccinated," says report author Mark=20 Slifka of the Vaccine and Gene Therapy Institute at = Oregon=20 Health and Science University. "We have some level of = hereditary=20 immunity in at least half the population, so we're fortunate = that=85we=20 have a readily available vaccine that can be used to defend = against=20 this threat."

But what if smallpox could somehow be genetically = modified? As=20 shown on PBS's NOVA, scientists in the former = Soviet Union=20 used genetic engineering to create mixtures of diseases, or = "super=20 bugs." "Recombination of smallpox with other small viruses = was=20 studied at [the Russian lab] Vector from approximately 1985 = to=20 1991," Serguei Popov, a former scientist in the = Russian=20 biological warfare program who now works at Analex, = an=20 information technology, engineering services, and medical=20 engineering and research company focusing on national = security,=20 wrote in an email to ScienCentral.

"The fact that they messed with smallpox still continues = to=20 astound a lot of people in the national security and in the=20 scientific community," Amy=20 Smithson, director of the Chemical and Biological Weapons = Nonproliferation=20 Project at the Henry L. Stimson Center, told NOVA, = "because=20 smallpox is so highly contagious and has throughout the = history of=20 mankind occasionally erupted and just wiped out millions and = millions of people at a time."

3D"smallpox
Smallpox vaccine=20 production.
image: = ABC=20 News
"It is fairly = easy for=20 experienced molecular biologists to engineer pox viruses to = carry=20 mutated genes or even to plug in entirely new genes, such as = toxins=20 from other bugs," says Slifka. But ultimately, he says the smallpox vaccine would stand up to a = modified=20 version of the bug. "There's been several conspiracy = theories such=20 as, 'what if the smallpox virus was mutated to become more = virulent,=20 would the smallpox vaccine still work?' My guess would be = yes,=20 indeed it would. It's impossible to mutate all of the = different=20 parts of the virus that your immune system recognizes. Some = part of=20 the virus would have to be maintained, and the smallpox = vaccine=20 would still be able to ID those and induce protective = immunity."

Furthermore, he says that a stronger version of the virus = might=20 not be something bioterrorists would actually want. = "Basically, a=20 super-virus=85would kill too rapidly. That would be = counterintuitive=20 for an epidemic. If the virus kills you rapidly, then it = would=20 reduce the spread." Slifka cites Ebola as an example of a = powerful=20 virus that kills quickly, but doesn't spread well. "Also, = people=20 would get sick more rapidly and would be more readily = identified by=20 the healthcare professionals," says Slifka. "So instead of = causing a=20 worse outbreak, a more virulent strain of virus=97if it = could be=20 developed=97would actually result in a smaller outbreak." =

Slifka also points out the potential for a "boomerang" = effect.=20 "If someone was to release smallpox in the U.S., who is to = say that=20 it wouldn't spread back to the country that sponsored this = type of=20 bioterrorism? Because not every country has their own = stockpile of=20 smallpox vaccine or VIG (vaccinia immune globulin), a terrorist = would have=20 to contemplate the possibility of what would happen if this=20 infectious agent somehow was release or imported back into = their own=20 country. How well would their own health care system be able = to deal=20 with it?"


 
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