From: Subject: =?Windows-1252?Q?Rapid_Molecular_Detection_of_Tuberculosis_and_Rifampin_R?= =?Windows-1252?Q?esistance_=97_NEJM?= Date: Thu, 2 Sep 2010 14:03:43 -0700 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0000_01CB4AA7.A6ECED10" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5931 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01CB4AA7.A6ECED10 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nejm.org/doi/full/10.1056/NEJMoa0907847 =EF=BB=BF Rapid = Molecular Detection of Tuberculosis and Rifampin Resistance =E2=80=94 = NEJM
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Original Article

Rapid Molecular Detection of Tuberculosis and Rifampin = Resistance

Catharina C. Boehme, M.D., Pamela Nabeta, M.D., Doris = Hillemann, Ph.D., Mark P. Nicol, Ph.D., Shubhada Shenai, Ph.D., Fiorella = Krapp,=20 M.D., Jenny Allen, B.Tech., Rasim Tahirli, M.D., Robert Blakemore, B.S., = Roxana=20 Rustomjee, M.D., Ph.D., Ana Milovic, M.S., Martin Jones, Ph.D., Sean M. = O'Brien,=20 Ph.D., David H. Persing, M.D., Ph.D., Sabine Ruesch-Gerdes, M.D., = Eduardo=20 Gotuzzo, M.D., Camilla Rodrigues, M.D., David Alland, M.D., and Mark D. = Perkins,=20 M.D.

September 1, 2010 (10.1056/NEJMoa0907847) =

Abstract

Background

Global control of tuberculosis is hampered by slow, insensitive = diagnostic=20 methods, particularly for the detection of drug-resistant forms and in = patients with human immunodeficiency virus infection. Early detection = is=20 essential to reduce the death rate and interrupt transmission, but the = complexity and infrastructure needs of sensitive methods limit their=20 accessibility and effect.

Full Text of Background...

Methods

We assessed the performance of Xpert MTB/RIF, an automated = molecular test=20 for Mycobacterium tuberculosis (MTB) and resistance to = rifampin=20 (RIF), with fully integrated sample processing in 1730 patients with = suspected=20 drug-sensitive or multidrug-resistant pulmonary tuberculosis. Eligible = patients in Peru, Azerbaijan, South Africa, and India provided three = sputum=20 specimens each. Two specimens were processed with = N-acetyl-L-cysteine=20 and sodium hydroxide before microscopy, solid and liquid culture, and = the=20 MTB/RIF test, and one specimen was used for direct testing with = microscopy and=20 the MTB/RIF test.

Full Text of Methods...

Results

Among culture-positive patients, a single, direct MTB/RIF test = identified=20 551 of 561 patients with smear-positive tuberculosis (98.2%) and 124 = of 171=20 with smear-negative tuberculosis (72.5%). The test was specific in 604 = of 609=20 patients without tuberculosis (99.2%). Among patients with = smear-negative,=20 culture-positive tuberculosis, the addition of a second MTB/RIF test = increased=20 sensitivity by 12.6 percentage points and a third by 5.1 percentage = points, to=20 a total of 90.2%. As compared with phenotypic drug-susceptibility = testing,=20 MTB/RIF testing correctly identified 200 of 205 patients (97.6%) with=20 rifampin-resistant bacteria and 504 of 514 (98.1%) with = rifampin-sensitive=20 bacteria. Sequencing resolved all but two cases in favor of the = MTB/RIF=20 assay.

Full Text of Results...

Conclusions

The MTB/RIF test provided sensitive detection of tuberculosis and = rifampin=20 resistance directly from untreated sputum in less than 2 hours with = minimal=20 hands-on time. (Funded by the Foundation for Innovative New = Diagnostics.)

Full Text of Discussion...

Read the Full Article...

Source Information

From the Foundation for Innovative New Diagnostics, Geneva (C.C.B., = P.N.,=20 M.D.P.); Forschungszentrum Borstel, Borstel, Germany (D.H., S.R.-G.); = the=20 Department of Clinical Laboratory Sciences, University of Cape Town, = and=20 National Health Laboratory Service, Cape Town (M.P.N., A.M.), and the = Unit for=20 Clinical and Biomedical TB Research, South African Medical Research = Council,=20 Durban (J.A., R.R.) =E2=80=94 all in South Africa; P.D. Hinduja = National Hospital and=20 Medical Research Centre (Hinduja), Mumbai, India (S.S., C.R.); = Instituto de=20 Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano = Heredia, Lima, Peru (F.K., E.G.); Special Treatment Institution, Baku, = Azerbaijan (R.T.); the Division of Infectious Diseases, New Jersey = Medical=20 School, University of Medicine and Dentistry of New Jersey, Newark = (R.B.,=20 D.A.); Cepheid, Sunnyvale, CA (M.J., D.H.P.); and the Department of=20 Biostatistics and Bioinformatics, Duke University Medical Center, = Durham, NC=20 (S.M.O.).

Address reprint requests to Dr. Boehme at the Foundation for = Innovative New=20 Diagnostics, Ave. de Bud=C3=A9 16, 1202 Geneva, Switzerland, or at catharina.boehme@fin= ddiagnostics.org.=20

Media in This Article

Figure 1Enrollment and Outcomes.Figure 2Assay Procedure for the MTB/RIF = Test.

Article Activity

Article

Only a small fraction of the estimated 500,000 patients who have=20 multidrug-resistant tuberculosis and 1.37 million patients who have=20 coinfection with tuberculosis and the human immunodeficiency virus = (HIV)=20 worldwide each year have access to sufficiently sensitive case = detection or=20 drug-susceptibility testing.1 Diagnostic delay, aggravated by the=20 disproportionate frequency of smear-negative disease in HIV-associated = tuberculosis, is common.2-5 The failure to quickly recognize and = treat=20 affected patients leads to increased mortality, secondary resistance=20 (including extensively drug-resistant tuberculosis), and ongoing=20 transmission.6,7 The complexity of mycobacterial culture = and=20 current nucleic acid=E2=80=93amplification technologies for the = detection of=20 tuberculosis and multidrug-resistant tuberculosis8 and the need for the associated = infrastructure=20 restrict the use of such tests to reference laboratories.

To respond to the urgent need for simple and rapid diagnostic tools = at the=20 point of treatment in high-burden countries,9 a fully automated molecular test for = tuberculosis=20 case detection and drug-resistance testing was developed through = collaboration=20 in a public=E2=80=93private partnership. Xpert MTB/RIF, an automated = molecular test=20 for Mycobacterium tuberculosis (MTB) and resistance to = rifampin=20 (RIF), uses heminested real-time polymerase-chain-reaction (PCR) assay = to=20 amplify an MTB-specific sequence of the rpoB gene, which is = probed=20 with molecular beacons for mutations within the rifampin-resistance=20 determining region.10,11 Testing is carried out on the MTB/RIF = test=20 platform (GeneXpert, Cepheid), which integrates sample processing and = PCR in a=20 disposable plastic cartridge containing all reagents required for = bacterial=20 lysis, nucleic acid extraction, amplification, and amplicon = detection.12 The only manual step is the addition of = a=20 bactericidal buffer to sputum before transferring a defined volume to = the=20 cartridge. The MTB/RIF cartridge is then inserted into the GeneXpert = device,=20 which provides results within 2 hours.

In accordance with recommendations on design and conduct of = diagnostic=20 accuracy assessments,13 we undertook a multicenter, prospective = evaluation=20 of the MTB/RIF test to determine its sensitivity and specificity in = the=20 intended target population as compared with the best available = reference=20 standard.

Methods

Study Population

From July 2008 through March 2009, we conducted this study at five = trial=20 sites in Lima, Peru; Baku, Azerbaijan; Cape Town and Durban, South = Africa; and=20 Mumbai, India. We enrolled consecutive adults with symptoms suggestive = of=20 pulmonary tuberculosis or multidrug-resistant tuberculosis who were = able to=20 provide three sputum samples of at least 1.5 ml. Patients in the group = at risk=20 for pulmonary tuberculosis were eligible only if they had not received = a=20 tuberculosis medication within the past 60 days, whereas the group at = risk for=20 multidrug-resistant disease included patients who had undergone = previous=20 treatment, those with nonconverting pulmonary tuberculosis who were = receiving=20 therapy, and symptomatic contacts of patients with known = multidrug-resistant=20 disease. All patients were enrolled from populations that were = selected for=20 diversity in the prevalence of tuberculosis, HIV coinfection, and = multidrug=20 resistance. (For details regarding the sites, see the Supplementary=20 Appendix, available with the full text of this article at = NEJM.org.)

The study protocol was reviewed and approved by eight institutional = review=20 boards or technical committees at the ministerial level. The study was = conducted in accordance with the protocol=20 (available at NEJM.org). Written informed consent was obtained from = all=20 patients. Study participation did not alter the standard of = care.

Study Design and = Oversight

This study was designed and supervised by the sponsor, the = Foundation for=20 Innovative New Diagnostics (FIND). Additional development support was = provided=20 by the National Institutes of Health, Cepheid, and the Bill and = Melinda Gates=20 Foundation, none of which were involved in the design or conduct of = the study.=20 Data were collected by investigators at each study site, and = statistical=20 analyses were performed by a statistician who was not involved in data = collection. FIND authors wrote the first draft of the manuscript. All = authors=20 vouch for the accuracy and completeness of the data = reported.

Laboratory Methods

Patients meeting the clinical eligibility criteria were asked to = provide=20 three sputum specimens over a 2-day period (two spot samples and one = obtained=20 in the morning) (Figure=20 1Figure 1Enrollment and Outcomes.). In a = random=20 fashion, two of the three samples were processed with=20 N-acetyl-L-cysteine and sodium hydroxide = (NALC=E2=80=93NaOH),14 followed by centrifugation, and then = were=20 resuspended in 1.5 ml of phosphate buffer and subjected to microscopy = with=20 Ziehl=E2=80=93Neelsen staining, and cultivation on solid medium = (egg-based=20 L=C3=B6wenstein=E2=80=93Jensen15 or 7H11,16 with the latter medium used only in = Durban) and=20 liquid medium (BACTEC MGIT [mycobacteria growth indicator tube] 960 = culture;=20 BD Microbiology Systems), and the MTB/RIF test. The third sputum = sample was=20 tested directly by Ziehl=E2=80=93Neelsen microscopy and the MTB/RIF = test without=20 NALC=E2=80=93NaOH decontamination.

The first positive culture from each specimen underwent = confirmation of=20 M. tuberculosis species by MPT64 antigen detection (Capilia = TB, Tauns=20 Laboratories)17 and indirect drug-susceptibility testing = with the=20 proportion method on L=C3=B6wenstein=E2=80=93Jensen medium (for sites = in Lima, Durban, and=20 Baku) or MGIT SIRE18 (for sites in Cape Town and Mumbai). For = three=20 sites, conventional nucleic acid=E2=80=93amplification testing was = carried out on DNA=20 that was extracted from the NALC=E2=80=93NaOH centrifugation pellet of = the first=20 sputum sample with the use of Cobas Amplicor MTB (Roche) (in Cape Town = and=20 Mumbai) or ProbeTec ET MTB Complex Direct Detection Assay (BD) (in = Baku),=20 according to the manufacturer's instructions. At three sites, = drug-resistant=20 genotyping was carried out by line-probe assay with the use of the = Genotype=20 MTBDRplus assay (Hain Lifescience) performed from culture isolates (in = Baku)=20 or from the NALC=E2=80=93NaOH pellet of the second sputum sample (in = Cape Town and=20 Durban), according to the manufacturer's instructions, except that=20 smear-negative specimens were also tested.

All participating laboratories were quality-assured reference = laboratories.=20 Study laboratories for four sites were located within 5 km of the = enrollment=20 clinic and tested samples within 2 days after collection. Sputum = samples from=20 Baku were shipped to the German National Reference Laboratory in = Borstel for=20 testing 1 to 5 days after collection.

Repeat tuberculosis analyses (smear, culture, MTB/RIF test, = radiography,=20 and clinical workup) were performed in patients who had smear- and=20 culture-negative samples if the MTB/RIF test or other nucleic=20 acid=E2=80=93amplification test was positive or if the patient was = selected by the=20 central database as a random control for follow-up. The final = diagnosis for=20 patients undergoing repeat analyses was established on the basis of=20 conventional laboratory results and clinical information by clinical = review=20 committees composed of three local tuberculosis clinicians. HIV = results were=20 obtained by review of clinical records and were available for only a = subgroup=20 of patients. Bias was minimized through blinding, since technicians = performing=20 molecular and reference tests were not aware of the results of other = tests.=20 The interpretation of data from MTB/RIF tests was software-based and=20 independent of the user. Clinical teams and review committees did not = have=20 access to nucleic acid=E2=80=93amplification test results. All study = coordinators=20 received lists of patients for follow-up but not the reasons for=20 follow-up.

Categories for Analysis

Patients were divided into four categories for analysis: those with = smear-=20 and culture-positive pulmonary tuberculosis; those with = smear-negative,=20 culture-positive pulmonary tuberculosis; those with no bacteriologic = evidence=20 of tuberculosis who had improvement without treatment (no = tuberculosis); and=20 those who were smear- and culture-negative for pulmonary tuberculosis = who=20 nonetheless were treated for tuberculosis on the basis of clinical and = radiologic findings (clinical tuberculosis). A smear-positive case was = defined=20 as at least two smears of scanty grade (1 to 10 acid-fast bacilli per = 100=20 fields) or one or more smears of 1+ or more (10 to 99 bacilli per 100 = fields).=20 A culture-positive case was defined as positive results on at least = one of=20 four culture vials. Because a clear final diagnosis was required, = patients=20 with an indeterminate diagnosis were excluded from the main analysis = if there=20 was a negative culture result while the patient was receiving = tuberculosis=20 treatment (for patients with suspected multidrug resistance), = contamination of=20 at least three of four cultures, growth of nontuberculous mycobacteria = only,=20 indeterminate phenotypic rifampin susceptibility, a negative culture = with a=20 positive sputum smear, or suspected cross-contamination of cultures = (i.e.,=20 only one of four cultures had positive results after >28 days to = growth in=20 MGIT or <20 colonies in L=C3=B6wenstein=E2=80=93Jensen medium) or = if the patient died or=20 was lost to follow-up.

MTB/RIF Test

The MTB/RIF test was performed as described previously19,20 (Figure=20 2Figure 2Assay Procedure for the MTB/RIF = Test.). Two=20 laboratory technicians were trained as operators and passed = proficiency=20 testing after four runs per person. Sample reagent was added in a 2:1 = ratio to=20 untreated sputum and in a 3:1 ratio to decontaminated sputum pellets. = The=20 additional sample reagent in pellets was necessary to meet the volume=20 requirements for the assay sample. The closed sputum container was = manually=20 agitated twice during a 15-minute period at room temperature before 2 = ml of=20 the inactivated material was transferred to the test cartridge = (equivalent to=20 0.7 ml of untreated sputum or 0.5 ml of decontaminated pellet). = Cartridges=20 were inserted into the test platform, which was located in the = microscopy room=20 or another general-purpose laboratory space. The electronic results = were sent=20 directly from the MTB/RIF test system to the central = database.

Sequencing

Bidirectional sequencing was performed on the 81-bp rpoB = core=20 region of culture isolates in all rifampin-resistant and discordant = strains=20 with forward (CGTGGAGGCGATCACACCGCAGAC) and reverse = (AGCTCCAGCCCGGCACGCTCACGT)=20 primers with the use of the BigDye Terminator Cycle Sequencing kit, = according=20 to the manufacturer's recommendations, in a 3130xl Genetic Analyzer = (Applied=20 Biosystems). Traces were analyzed with ABI sequence-analysis software, = version=20 5.2.0.

Statistical Analysis

Sensitivity and specificity for the MTB/RIF test were estimated for = a=20 single direct test, a single test on a pelleted sample, the = combination of two=20 tests (one direct and one pelleted), and the combination of three = tests (one=20 direct and two pelleted). Combinations were classified as positive if = at least=20 one of the component test results was positive. The indeterminate rate = was the=20 number of tests classified as =E2=80=9Cinvalid,=E2=80=9D = =E2=80=9Cerror,=E2=80=9D or =E2=80=9Cno result=E2=80=9D divided by=20 the total number performed. When results were indeterminate and = sufficient=20 sample remained, the assay was repeated once, and the second result = was used=20 for analysis. For analyzing the single direct test and the combination = of=20 three tests, Wilson's binomial method was used to calculate 95% = confidence=20 intervals.21 For all other intrapatient MTB/RIF = results, and=20 for comparisons across subgroups and testing methods, generalized = estimating=20 equations were used for calculating confidence intervals to account = for=20 within-patient clustering.22

Results

Patients

Of the 1462 patients (4386 samples) included in the analysis, 567 = (38.8%)=20 had smear- and culture-positive tuberculosis; 174 (11.9%) had = smear-negative,=20 culture-positive tuberculosis; 105 (7.2%) had clinically defined = tuberculosis;=20 and 616 (42.1%) had no clinical evidence of tuberculosis (Table=20 1Table 1Demographic and Clinical Characteristics of the = Patients,=20 Diagnosis Group at Enrollment, and Distribution in Final Diagnostic=20 Category.). Of patients with culture-positive samples, = 207 of=20 741 (27.9%) were found to have multidrug resistance on conventional=20 drug-susceptibility testing. A total of 113 patients were not eligible = for=20 testing because of an inadequate number of sputum samples (in 103 = patients) or=20 an inadequate volume of sputum samples (in 10). A total of 268 = patients were=20 excluded from the analysis for a variety of reasons, including 115 who = had=20 culture-negative samples but were receiving tuberculosis treatment at=20 enrollment because of suspected multidrug resistance (Figure=20 1).

Sensitivity and = Specificity

Case Detection

Among patients with culture-positive tuberculosis, the overall = sensitivity=20 of the MTB/RIF test was 97.6%. The sensitivity was 99.8% for smear- = and=20 culture-positive cases and 90.2% for smear-negative, culture-positive = cases,=20 with no significant variation in overall sensitivity across sites = (P=3D0.24 by=20 chi-square test) (Table=20 2Table 2Overall Sensitivity and Specificity of the = MTB/RIF Test,=20 According to the Number of Tests per Patient, as Compared with Three = Smears=20 and Four Cultures.). Testing of multiple specimens per = patient=20 had a modest effect over the yield of a single assay performed = directly on=20 sputum. The sensitivity of a single direct MTB/RIF test for = culture-confirmed=20 tuberculosis was 92.2% and rose to 96.0% with the additional testing = of a=20 pelleted sample. For the detection of smear-negative, culture-positive = tuberculosis, the sensitivity of the assay was 72.5% for one test, = 85.1% for=20 two tests, and 90.2% for three tests. A single, direct MTB/RIF test = identified=20 a greater proportion of culture-positive patients than did a single=20 L=C3=B6wenstein=E2=80=93Jensen culture (Table 1 in the Supplementary=20 Appendix). Among HIV-positive patients with pulmonary = tuberculosis, the=20 sensitivity of the MTB/RIF test was 93.9%, as compared with 98.4% in=20 HIV-negative patients (P=3D0.02). There was no significant difference = in=20 sensitivity between tests on untreated sputum and those on = decontaminated=20 pellet (P=3D0.16).

The estimated specificity was 99.2% for a single direct MTB/RIF = test, 98.6%=20 for two MTB/RIF tests, and 98.1% for three MTB/RIF tests. At sites = performing=20 alternative nucleic acid=E2=80=93amplification testing, the = sensitivity of the MTB/RIF=20 test performed directly on sputum was higher than that of Amplicor = (94.6% vs.=20 86.8%, P<0.01) and similar to that of ProbeTec (83.7% vs. 83.9%, = P=3D0.96)=20 performed on extracted DNA from sputum pellets. The specificity of the = MTB/RIF=20 test did not differ significantly from that of Amplicor or Probetec = (Table 2=20 in the Supplementary=20 Appendix).

Detection of = Multidrug=20 Resistance

Table=20 3Table 3Sensitivity and Specificity of the MTB/RIF Test = for the=20 Detection of Rifampin and Multidrug Resistance, as Compared with = Phenotypic=20 Drug-Susceptibility Testing Alone and in Combination with Sequencing = of=20 Discrepant Cases, According to Site. shows the = sensitivity and=20 specificity of the MTB/RIF test for the detection of rifampin and = multidrug=20 resistance (resistance to both rifampin and isoniazid). For 15 of 718 = patients=20 for whom results on the MTB/RIF test were discrepant on phenotypic = testing,=20 sequencing confirmed resistance-associated rpoB mutations in = nine=20 strains that were identified as rifampin-sensitive on = drug-susceptibility=20 testing, determined the presence of a wild-type allele in one strain = deemed=20 rifampin-resistant on drug-susceptibility testing, and identified 3 = patients=20 with mixed infection containing wild-type and mutant strains in the = same=20 culture. Taking sequencing results into account, the MTB/RIF test = correctly=20 detected rifampin resistance in 209 of 211 patients (99.1% = sensitivity) and in=20 all 506 patients with rifampin susceptibility (100% specificity).

The rpoB mutations found in this study were representative = of the=20 global situation: 16 different mutations were identified, but a = limited=20 number, notably in codons 516, 526 and 531, accounted for almost all = resistant=20 strains.

Using the South African samples, we compared the performance of the = direct=20 Genotype MTBDRplus assay with that of the MTB/RIF test. In = smear-positive=20 sputum samples, the MTBDRplus assay showed a sensitivity equivalent to = that of=20 the MTB/RIF test. However, in samples from smear-negative, = culture-positive=20 patients, for which the MTBDRplus assay is not indicated, the = MTBDRplus assay=20 provided a false negative result in 37 of 67 samples (55.2%).

In a subgroup of 115 patients with culture-negative tuberculosis = who had=20 suspected multidrug resistance and were receiving tuberculosis = treatment (and=20 who were excluded from the main analysis), 51 had positive results on = the=20 MTB/RIF test, and rifampin resistance was detected in 8. We observed = that all=20 8 patients were later started on second-line therapy for treatment = failure by=20 physicians who were unaware of the results on MTB/RIF testing. In = comparison,=20 none of 8 randomly selected patients from the same cohort with = positive=20 results on MTB/RIF testing that did not detect rifampin resistance = were given=20 second-line tuberculosis treatment. Although the manufacturer = currently=20 recommends that the MTB/RIF test be used for patients with suspected=20 tuberculosis who have not received treatment, our data provide a first = indication that the test also detects multidrug-resistant tuberculosis = in=20 patients who are receiving therapy, even after culture=20 conversion.

Indeterminate Rate

The MTB/RIF test was indeterminate in 192 of 5190 tests performed = (3.7%), a=20 rate that was lower than the overall culture-contamination rate (5.5%) = in 381=20 of 6920 MGIT and L=C3=B6wenstein=E2=80=93Jensen cultures (P<0.001). = Allowing for one=20 repeat test, the indeterminate rate dropped to 1.2% (63 of 5190 = tests). Valid=20 results were obtained in 129 of 139 repeat tests (92.8%). No patient = had=20 indeterminate results on all samples tested. A total of 20 of 2072 = samples=20 (1.0%) with positive results had an indeterminate result for rifampin=20 resistance. These indeterminate rifampin results all occurred in=20 smear-negative, culture-positive sputum samples with a very late cycle = threshold (35 to 37 cycles) in the MTB/RIF test. A software change = allowing=20 the assay to analyze results for up to 40 cycles would have eliminated = 19 of=20 the 20 indeterminate results without affecting the specificity of the=20 assay.

Discussion

In our study, an assay that was designed for point-of-treatment use = in=20 low-income countries accurately detected pulmonary tuberculosis and = screened=20 for rifampin resistance. This assay identified more than 97% of all = patients=20 with culture-confirmed tuberculosis who met the inclusion criteria, = including=20 more than 90% of patients with smear-negative disease. Performance = both for=20 case detection and discrimination of rifampin resistance was similar = across=20 diverse sites, suggesting that the findings are likely to be widely=20 applicable. In view of the low sensitivity of smear microscopy for the = diagnosis of tuberculosis in patients with HIV infection, the = increased=20 sensitivity of the MTB/RIF test =E2=80=94 notably, among patients with = smear-negative=20 tuberculosis =E2=80=94 at the two South African sites with 60 to 80% = prevalence of HIV=20 infection is encouraging.

There are several reasons why the findings of this study might not=20 translate widely into improved care for patients with tuberculosis. = First,=20 only reference facilities were used in the study, and it is not = certain that=20 our findings would be replicated in microscopy centers, health posts, = and=20 other point-of-treatment settings where temperature and electricity = supply=20 will be more variable and training issues will be more relevant. = However,=20 qualitative questionnaires that were completed during the study = suggested that=20 users considered 2 to 3 days a sufficient duration of training for = technicians=20 without previous molecular experience (as compared with 2 weeks for=20 Ziehl=E2=80=93Neelsen microscopy). The relative simplicity of the = MTB/RIF test, plus=20 its hands-on time of under 15 minutes and its unambiguous readout, is=20 advantageous, whereas the need for annual calibration was identified = as a=20 challenge for implementation at peripheral laboratories, especially in = rural=20 areas. Large-scale projects to show the feasibility and effect of = MTB/RIF=20 testing at such sites are under way.

Second, to achieve great simplicity of use, the MTB/RIF test uses=20 sophisticated technology, which is costly to manufacture. Although = FIND has=20 negotiated concessionary pricing for public-sector programs in = low-income=20 countries and is working to further lower the costs of testing, the = costs of=20 instruments and tests will still be considerably higher than those for = microscopy, which is all that is currently available in peripheral = health care=20 settings in many countries. However, MTB/RIF testing could be less = costly than=20 implementation of culture and drug-susceptibility testing.

Globally, ineffective tuberculosis detection and the rise of = multidrug=20 resistance and extensively drug-resistant tuberculosis have led to = calls for=20 dramatic expansion of culture capability and drug-susceptibility = testing in=20 countries in which the disease is endemic.23 Unfortunately, the infrastructure and = trained=20 personnel required for such testing are not available except in a = limited=20 number of reference centers, and results of testing are often not = available=20 for at least 4 months, which dramatically reduces its clinical = utility.24,25 The complexity of standard nucleic=20 acid=E2=80=93amplification tests prevents the expansion of this = method. The MTB/RIF=20 test automates DNA extraction, amplification, and detection inside a = test=20 cartridge that is never reopened, with little chance of amplicon=20 contamination. Specimen processing is simplified to a single = nonprecise step=20 that both liquefies and inactivates sputum, which results in a = reduction in=20 viable tubercle bacilli of 6 to 8 logs and eliminates the necessity = for a=20 biosafety cabinet. Data from a recent study confirm that the MTB/RIF = assay=20 generates no infectious aerosols.26 These features of simplicity and safety = of use=20 could allow for cost-effective and highly sensitive detection of = tuberculosis=20 and drug resistance outside reference centers, which would increase = access to=20 testing and decrease delays in diagnosis, without the need to build = large=20 numbers of laboratories equipped for advanced biosafety.

This article (10.1056/NEJMoa0907847) was published on September 1, = 2010, at=20 NEJM.org.

Supported by FIND (for clinical evaluation and assay development) = and=20 grants from the National Institutes of Health (AI52523), Cepheid, and = the Bill=20 and Melinda Gates Foundation (for assay development).

Disclosure=20 forms provided by the authors are available with the full text of = this=20 article at NEJM.org.

Source Information

From the Foundation for Innovative New Diagnostics, Geneva (C.C.B., = P.N.,=20 M.D.P.); Forschungszentrum Borstel, Borstel, Germany (D.H., S.R.-G.); = the=20 Department of Clinical Laboratory Sciences, University of Cape Town, = and=20 National Health Laboratory Service, Cape Town (M.P.N., A.M.), and the = Unit for=20 Clinical and Biomedical TB Research, South African Medical Research = Council,=20 Durban (J.A., R.R.) =E2=80=94 all in South Africa; P.D. Hinduja = National Hospital and=20 Medical Research Centre (Hinduja), Mumbai, India (S.S., C.R.); = Instituto de=20 Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano = Heredia, Lima, Peru (F.K., E.G.); Special Treatment Institution, Baku, = Azerbaijan (R.T.); the Division of Infectious Diseases, New Jersey = Medical=20 School, University of Medicine and Dentistry of New Jersey, Newark = (R.B.,=20 D.A.); Cepheid, Sunnyvale, CA (M.J., D.H.P.); and the Department of=20 Biostatistics and Bioinformatics, Duke University Medical Center, = Durham, NC=20 (S.M.O.).

Address reprint requests to Dr. Boehme at the Foundation for = Innovative New=20 Diagnostics, Ave. de Bud=C3=A9 16, 1202 Geneva, Switzerland, or at catharina.boehme@fin= ddiagnostics.org.=20

We thank the clinical and laboratory teams at the partner sites for = their=20 efforts in the implementation, conduct, and timely completion of the = study;=20 Justine de Grandpr=C3=A9 and Dr. Ranald Sutherland for their = continuous technical=20 support and project management during assay development; and FIND = logistics=20 officer Nora Champouillon and data manager Pierrick Gonnet for = facilitating=20 the project.

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PADDING-TOP: 0px } A { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } ABBR { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } ACRONYM { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } ADDRESS { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } BIG { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } CITE { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } CODE { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } DEL { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } DFN { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } EM { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } FONT { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } IMG { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } INS { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } KBD { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } Q { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } S { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } SAMP { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } SMALL { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } STRIKE { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } STRONG { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } SUB { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } SUP { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } TT { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } VAR { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } DL { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } DT { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } DD { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } OL { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } UL { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } LI { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } FIELDSET { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } FORM { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } LABEL { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } LEGEND { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } TABLE { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } CAPTION { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } TBODY { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } TFOOT { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } THEAD { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } TR { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } TH { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } TD { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0px; FONT-STYLE: = inherit; MARGIN: 0px; OUTLINE-STYLE: none; OUTLINE-COLOR: invert; = PADDING-LEFT: 0px; OUTLINE-WIDTH: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 100%; VERTICAL-ALIGN: baseline; BORDER-TOP: 0px; FONT-WEIGHT: inherit; = BORDER-RIGHT: 0px; PADDING-TOP: 0px } BODY { PADDING-BOTTOM: 20px; LINE-HEIGHT: 1; BACKGROUND: white; COLOR: black; = FONT-SIZE: 100% } BODY { FONT-FAMILY: arial, sans-serif; COLOR: #333 } INPUT { FONT-FAMILY: arial, sans-serif; COLOR: #333 } TEXTAREA { FONT-FAMILY: arial, sans-serif; COLOR: #333 } OL { LIST-STYLE-TYPE: none; LIST-STYLE-IMAGE: none } UL { LIST-STYLE-TYPE: none; LIST-STYLE-IMAGE: none } #content { PADDING-BOTTOM: 15px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } H3 { FONT-WEIGHT: bold } TABLE { BORDER-SPACING: 0; BORDER-COLLAPSE: separate } INPUT.text { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 2px; PADDING-LEFT: 2px; PADDING-RIGHT: 2px; COLOR: #666; = BORDER-TOP: #ccc 1px solid; BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: = 2px } TEXTAREA { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 2px; PADDING-LEFT: 2px; PADDING-RIGHT: 2px; COLOR: #666; = BORDER-TOP: #ccc 1px solid; BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: = 2px } INPUT.submit { PADDING-BOTTOM: 1px; PADDING-LEFT: 1px; PADDING-RIGHT: 1px; = PADDING-TOP: 1px } A { COLOR: #006892; TEXT-DECORATION: none } A:hover { TEXT-DECORATION: underline } IMG { DISPLAY: block } IMG.entityD { DISPLAY: inline } IMG.entityA { DISPLAY: inline } IMG.entityB { DISPLAY: inline } IMG.entityC { DISPLAY: inline } .moreLink { FONT-SIZE: 0.7em } SPAN.moreLink { TEXT-ALIGN: right } .moreLink A { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blueRigh= tArrow.gif) no-repeat right 51%; FONT-WEIGHT: bold } .nextLink A { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blueRigh= tArrow.gif) no-repeat right 51%; FONT-WEIGHT: bold } .moreLink SPAN { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blackRig= htArrow.gif) no-repeat right 51%; FONT-WEIGHT: normal } .nextLink SPAN { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blackRig= htArrow.gif) no-repeat right 51%; FONT-WEIGHT: normal } .previousLink A { PADDING-LEFT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blueLeft= Arrow.gif) no-repeat left 51%; FONT-WEIGHT: bold } .previousLink SPAN { PADDING-LEFT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blackLef= tArrow.gif) no-repeat left 51%; FONT-WEIGHT: normal } DIV.alert { BORDER-BOTTOM: #f30 1px solid; BORDER-LEFT: #f30 1px solid; = PADDING-BOTTOM: 5px; BACKGROUND-COLOR: #f8f8f8; MARGIN: 10px 0px; = PADDING-LEFT: 10px; PADDING-RIGHT: 10px; FONT-SIZE: 0.75em; BORDER-TOP: = #f30 1px solid; BORDER-RIGHT: #f30 1px solid; PADDING-TOP: 5px } STRONG { FONT-WEIGHT: bold } .shown { DISPLAY: block } .hidden { DISPLAY: none } BLOCKQUOTE { PADDING-BOTTOM: 8px; PADDING-LEFT: 20px; PADDING-RIGHT: 20px; = PADDING-TOP: 0px } .journal { FONT-STYLE: italic } .errorMessage { BORDER-BOTTOM: #f30 1px solid; BORDER-LEFT: #f30 1px solid; = PADDING-BOTTOM: 10px; BACKGROUND-COLOR: #f8f8f8; MARGIN: 10px 0px; = PADDING-LEFT: 10px; PADDING-RIGHT: 10px; FONT-SIZE: 0.72em; BORDER-TOP: = #f30 1px solid; BORDER-RIGHT: #f30 1px solid; PADDING-TOP: 10px } .infoMessage { BORDER-BOTTOM: #f30 1px solid; BORDER-LEFT: #f30 1px solid; = PADDING-BOTTOM: 10px; BACKGROUND-COLOR: #f8f8f8; MARGIN: 10px 0px; = PADDING-LEFT: 10px; PADDING-RIGHT: 10px; FONT-SIZE: 0.72em; BORDER-TOP: = #f30 1px solid; BORDER-RIGHT: #f30 1px solid; PADDING-TOP: 10px } .infoMessage { BORDER-BOTTOM: #999 1px solid; BORDER-LEFT: #999 1px solid; = BACKGROUND-COLOR: #f8f8f8; BORDER-TOP: #999 1px solid; FONT-WEIGHT: = bold; BORDER-RIGHT: #999 1px solid } .more { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blueRigh= tArrow.gif) no-repeat right 51% } .articlePubdate { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 0.65em; 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url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/dot-on.g= if) no-repeat } .jcarousel-scroll { TEXT-ALIGN: center; MARGIN-TOP: 10px } .jcarousel-scroll FORM { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } .jcarousel-scroll SELECT { FONT-SIZE: 75% } .jcarousel-skin-nejm-noborder .jcarousel-item-noborder { WIDTH: 275px; HEIGHT: 75px } #galleryContent-next { MARGIN-BOTTOM: -10px; FONT-SIZE: 11px; CURSOR: pointer; = TEXT-DECORATION: underline } #galleryContent-prev { MARGIN-BOTTOM: -10px; FONT-SIZE: 11px; CURSOR: pointer; = TEXT-DECORATION: underline } #count { PADDING-LEFT: 5px; FONT-FAMILY: Arial, Helvetica, sans-serif; CLEAR: = both; FONT-SIZE: 11px } #content { POSITION: relative; PADDING-BOTTOM: 30px; PADDING-LEFT: 0px; WIDTH: = 607px; PADDING-RIGHT: 15px; FLOAT: left; PADDING-TOP: 15px } #ie6 #content { WIDTH: 610px } .wide#content { WIDTH: 938px } #rightRail { BORDER-LEFT: #ccc 1px solid; PADDING-BOTTOM: 30px; WIDTH: 314px; FLOAT: = left; MARGIN-LEFT: -1px } BODY.gateway.article #rightRail { BORDER-LEFT: medium none; MARGIN-LEFT: 0px } BODY.gateway.article #ie6 #subscriberBenefits IMG { WIDTH: 295px } .threeColumn#content .center { MARGIN: 0px 0px 0px 5px; WIDTH: 413px; FLOAT: left; COLOR: #333 } .threeColumn#content .left { WIDTH: 179px; MARGIN-BOTTOM: 20px; FLOAT: left } .mynejm .threeColumn#content .center { WIDTH: 186px; FLOAT: right; COLOR: #333 } .mynejm .threeColumn#content .left { WIDTH: 422px; FLOAT: left } #signInMessage { BORDER-BOTTOM: #ccc 1px solid; TEXT-ALIGN: center; PADDING-BOTTOM: = 15px; BACKGROUND-COLOR: #eff1ff; MARGIN: -15px; PADDING-LEFT: 15px; = PADDING-RIGHT: 15px; PADDING-TOP: 15px } #signInMessage .head { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT: bold = 0.9em "times new roman"; COLOR: #f30; PADDING-TOP: 0px } #signInMessage P { FONT-SIZE: 0.75em } #accessOptions { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 15px; BACKGROUND-COLOR: #eff1ff; PADDING-LEFT: 15px; = PADDING-RIGHT: 15px; MARGIN-BOTTOM: 15px; FONT-SIZE: 1em; BORDER-TOP: = #ccc 1px solid; BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } #accessOptions H2 { FONT: bold 1em "times new roman"; COLOR: #f30 } #accessOptions P.head { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 5px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; COLOR: #333333; FONT-WEIGHT: bold; PADDING-TOP: 0px } #accessOptions .accessOption { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 15px; BACKGROUND-COLOR: #fff; MARGIN: 15px 0px; = PADDING-LEFT: 15px; PADDING-RIGHT: 15px; BORDER-TOP: #ccc 1px solid; = BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } #accessOptions .accessOption P.head { MARGIN: 0px 0px 5px; COLOR: #333333; FONT-WEIGHT: bold } .mediaGatewayBody .right #accessOptions .accessOption { BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; PADDING-BOTTOM: = 0px; MARGIN: 5px 0px 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = BACKGROUND: none transparent scroll repeat 0% 0%; FONT-SIZE: 1.2em; = BORDER-TOP: medium none; BORDER-RIGHT: medium none; PADDING-TOP: 0px } .examGatewayBody .right #accessOptions .accessOption { BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; PADDING-BOTTOM: = 0px; MARGIN: 5px 0px 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = BACKGROUND: none transparent scroll repeat 0% 0%; FONT-SIZE: 1.2em; = BORDER-TOP: medium none; BORDER-RIGHT: medium none; PADDING-TOP: 0px } #accessOptions .rule { BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/solidrul= eccc.gif) repeat-x center center } #accessOptions SPAN.moreLink { TEXT-ALIGN: right; FONT-SIZE: 1em } #accessOptions SPAN.moreLink A { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blueRigh= tArrow.gif) no-repeat right 6px; FONT-WEIGHT: normal } #accessOptions .featuredOffer { =09 } #accessOptions .purchaseOptions { =09 } #accessOptions .printSubscriberOptions { BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; PADDING-BOTTOM: = 0px; BACKGROUND-COLOR: inherit; MARGIN: 0px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; BORDER-TOP: medium none; BORDER-RIGHT: medium none; = PADDING-TOP: 0px } #accessOptions .printSubscriberOptions P.head { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } #subscriberBenefits { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 15px; MARGIN: 15px 0px; PADDING-LEFT: 15px; = PADDING-RIGHT: 15px; FONT-SIZE: 1em; BORDER-TOP: #ccc 1px solid; = BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } #subscriberBenefits LI.right { TEXT-ALIGN: right; PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 0px } #subscriberBenefits UL { PADDING-BOTTOM: 5px; PADDING-LEFT: 5px; PADDING-RIGHT: 5px; FONT-SIZE: = 0.7em; PADDING-TOP: 5px } #subscriberBenefits LI { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .article #subscriberBenefits P.head { MARGIN: 0px 0px 5px; COLOR: #333333; FONT-WEIGHT: bold } #registeredUserBenefits { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 15px; BACKGROUND-COLOR: #eff1ff; MARGIN: 15px 0px; = PADDING-LEFT: 15px; PADDING-RIGHT: 15px; FONT-SIZE: 1em; BORDER-TOP: = #ccc 1px solid; BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } #registeredUserBenefits .head { DISPLAY: inline; FONT: bold 0.8em "times new roman" } #registeredUserBenefits UL { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = MARGIN-LEFT: 14px; FONT-SIZE: 0.7em; PADDING-TOP: 0px } #registeredUserBenefits LI { TEXT-ALIGN: left; LIST-STYLE-TYPE: disc } DIV.rightGreyBox { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 10px; BACKGROUND-COLOR: #f8f8f8; MARGIN: 0pt 0pt 15px = 0px; PADDING-LEFT: 15px; PADDING-RIGHT: 15px; BORDER-TOP: #ccc 1px = solid; BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } #licenseBox { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 10px; BACKGROUND-COLOR: #f8f8f8; MARGIN: 0pt 0pt 15px = 0px; PADDING-LEFT: 15px; PADDING-RIGHT: 15px; BORDER-TOP: #ccc 1px = solid; BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } #mktmsgBox { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 10px; BACKGROUND-COLOR: #f8f8f8; MARGIN: 0pt 0pt 15px = 0px; PADDING-LEFT: 15px; PADDING-RIGHT: 15px; BORDER-TOP: #ccc 1px = solid; BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } #custServBox { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 10px; BACKGROUND-COLOR: #f8f8f8; MARGIN: 0pt 0pt 15px = 0px; PADDING-LEFT: 15px; PADDING-RIGHT: 15px; BORDER-TOP: #ccc 1px = solid; BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } #faqsBox { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 10px; BACKGROUND-COLOR: #f8f8f8; MARGIN: 0pt 0pt 15px = 0px; PADDING-LEFT: 15px; PADDING-RIGHT: 15px; BORDER-TOP: #ccc 1px = solid; BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } .commentForm .alertMessage { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 10px; BACKGROUND-COLOR: #f8f8f8; MARGIN: 0pt 0pt 15px = 0px; PADDING-LEFT: 15px; PADDING-RIGHT: 15px; BORDER-TOP: #ccc 1px = solid; BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } #mktmsgBox { BACKGROUND-COLOR: #eff1ff } #mktmsgBox UL { MARGIN: 0px 0px 10px } #licenseBox UL { MARGIN: 0px 0px 10px } #mktmsgBox LI { LINE-HEIGHT: 1.4em; LIST-STYLE-TYPE: disc; MARGIN-LEFT: 15px; = FONT-SIZE: 0.7em } #licenseBox LI { LINE-HEIGHT: 1.4em; LIST-STYLE-TYPE: disc; MARGIN-LEFT: 15px; = FONT-SIZE: 0.7em } DIV.rightGreyBox H3 { TEXT-TRANSFORM: uppercase; COLOR: #000000; FONT-SIZE: 0.95em } DIV.rightGreyBox LI { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; BACKGROUND: = no-repeat left 3px; FLOAT: none; COLOR: #666; FONT-SIZE: 0.92em; = FONT-WEIGHT: normal; PADDING-TOP: 0px } DIV.rightGreyBox LI SPAN { FONT-WEIGHT: bold } DIV.rightGreyBox LI .expire { COLOR: #ff3300; FONT-WEIGHT: normal } #rightRail P SPAN { COLOR: #ff3300; FONT-WEIGHT: normal } DIV.rightGreyBox UL { PADDING-TOP: 5px } DIV.rightGreyBox UL.nextGroup { PADDING-TOP: 12px } #mktmsgBox H3 { LINE-HEIGHT: 1.25em; MARGIN: 0px 0px 8px; FONT-SIZE: 0.7em; = FONT-WEIGHT: bold } #custServBox H3 { LINE-HEIGHT: 1.25em; MARGIN: 0px 0px 8px; FONT-SIZE: 0.7em; = FONT-WEIGHT: bold } #faqsBox H3 { LINE-HEIGHT: 1.25em; MARGIN: 0px 0px 8px; FONT-SIZE: 0.7em; = FONT-WEIGHT: bold } #licenseBox H3 { LINE-HEIGHT: 1.25em; MARGIN: 0px 0px 8px; FONT-SIZE: 0.7em; = FONT-WEIGHT: bold } #faqsBox P A.more { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blueRigh= tArrow.gif) no-repeat right center } #signInForm { WIDTH: 330px; OVERFLOW: hidden } #signInForm H2 { LINE-HEIGHT: 1.2em; MARGIN: 0px 0px 2px; FONT-SIZE: 0.87em; = FONT-WEIGHT: bold } #signInForm .deckhead { FONT-SIZE: 0.7em } #signInForm SPAN.moreLink A { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0.8em; = BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blueRigh= tArrow.gif) no-repeat right 51%; FONT-SIZE: 11px; FONT-WEIGHT: normal; = PADDING-TOP: 0px } #signInForm .formLine { TEXT-ALIGN: right; MARGIN: 9px 0px; FONT-SIZE: 0.75em } #signInForm .formLine .leftButton { TEXT-ALIGN: left; WIDTH: 185px; FLOAT: right } #signInForm .formLineLeft { TEXT-ALIGN: left; MARGIN: 10px 0px } #signInForm .formLine LABEL { PADDING-RIGHT: 7px; FONT-SIZE: 0.92em; VERTICAL-ALIGN: -1px; = FONT-WEIGHT: bold } #signInForm .formLine INPUT.text { WIDTH: 180px } #signInForm .formLineLeft INPUT { WIDTH: 60px } #signInForm .rightSection { MARGIN: 15px 0px 0px; WIDTH: 185px; FLOAT: right } #signInForm .rightSection .formLine { TEXT-ALIGN: left; CLEAR: both } #signInForm .rightSection { BORDER-TOP: #ccc 1px dotted } #signInForm .rightSection .formLine INPUT.checkbox { MARGIN: 0px; VERTICAL-ALIGN: -3px } #signInForm .rightSection .formLine LABEL.checkbox { MARGIN-LEFT: 1px; FONT-WEIGHT: normal } .requal#signInForm { BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; PADDING-BOTTOM: = 15px; WIDTH: 345px; FLOAT: left; BORDER-TOP: medium none; BORDER-RIGHT: = medium none } .requal#signInForm SPAN { FONT-SIZE: 11px } .requal#signInForm H1 { TEXT-ALIGN: center; MARGIN: 0px 0px 16px; WIDTH: 370px; COLOR: #999999; = FONT-SIZE: 0.92em; FONT-WEIGHT: bold } .requal#signInForm .rightSection { MARGIN-TOP: -10px; BORDER-TOP: 0px } .requal#signInForm .leftButton { MARGIN-TOP: 5px; MARGIN-BOTTOM: 10px } #forgotPwdForm { WIDTH: 330px; OVERFLOW: hidden } #forgotPwdForm H2 { LINE-HEIGHT: 1.2em; MARGIN: 0px 0px 7px; FONT-SIZE: 0.87em; = FONT-WEIGHT: bold } #forgotPwdForm P.note { FONT-SIZE: 0.77em } #forgotPwdForm .formLine { TEXT-ALIGN: right; MARGIN: 9px 0px; FONT-SIZE: 0.75em } #forgotPwdForm .formLine .leftButton { TEXT-ALIGN: left; WIDTH: 185px; FLOAT: right } #forgotPwdForm .formLine LABEL { PADDING-RIGHT: 7px; FONT-SIZE: 0.92em; VERTICAL-ALIGN: -1px; = FONT-WEIGHT: bold } #forgotPwdForm .formLine INPUT.text { WIDTH: 180px } #forgotPwdForm .formLine INPUT.error { WIDTH: 180px; COLOR: #f30 } #forgotPwdConfirm { WIDTH: 330px; OVERFLOW: hidden } #forgotPwdConfirm H2 { LINE-HEIGHT: 1.2em; MARGIN: 0px 0px 7px; FONT-SIZE: 0.87em; = FONT-WEIGHT: bold } #forgotPwdConfirm P.note { FONT-SIZE: 0.77em } .filterBank#content .left { WIDTH: 186px } #content .left .box .r { PADDING-RIGHT: 7px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/shadowri= ght.png) no-repeat right top } #content .left .box .topRow { DISPLAY: none } #content .left .box .b { BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/shadowbo= ttom.png) no-repeat left bottom; HEIGHT: 8px } #ie6 #content .left .box .b { LINE-HEIGHT: 8px } #content .left .box .br { PADDING-RIGHT: 7px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/shadowbo= ttomright.png) no-repeat right bottom } #ie6 #content .left .box .br { BACKGROUND-POSITION: right top } #content .left .box .content { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; WIDTH: = 170px; BORDER-TOP: #ccc 1px solid; BORDER-RIGHT: #ccc 1px solid } #content .left .box .wrap { PADDING-RIGHT: 0px } #content .left .boxHeader { BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/leftRail= BoxHeading.gif) repeat-x left top; HEIGHT: 33px } #content .left .boxContent { PADDING-BOTTOM: 5px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = BORDER-TOP: #ccc 1px solid; PADDING-TOP: 15px } #content .left .box H3 { PADDING-BOTTOM: 15px; TEXT-TRANSFORM: uppercase; PADDING-LEFT: 12px; = PADDING-RIGHT: 12px; FONT: bold 0.68em "times new roman"; PADDING-TOP: = 11px } #ie6 #content .left .box H3 { PADDING-BOTTOM: 10px } #content .left .boxBlock DIV.head { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 1.1em; FONT-WEIGHT: bold; PADDING-TOP: 0px } #content .left .boxBlock FORM { CLEAR: both; FONT-SIZE: 0.6em; FONT-WEIGHT: normal } #content .left .boxBlock FIELDSET * { VERTICAL-ALIGN: middle } #content .left .boxBlock { PADDING-BOTTOM: 15px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/twoToneR= uleBottom.gif) repeat-x left bottom; FONT-SIZE: 0.62em; FONT-WEIGHT: = bold; PADDING-TOP: 15px } #content .left .boxBlock FORM INPUT.volume { WIDTH: 26px } #content .left .boxBlock FORM INPUT.num { WIDTH: 20px } #content .left .boxBlock FORM SELECT.month { WIDTH: 64px } #content .left .boxBlock FORM INPUT.day { WIDTH: 20px } #content .left .boxBlock FORM INPUT.year { WIDTH: 26px } #content .left .boxBlock SPAN.moreLink { FONT-SIZE: 1.1em } #content .left .boxBlock UL LI { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 1.1em; FONT-WEIGHT: normal; PADDING-TOP: 0px } #content .left .last { BACKGROUND: none transparent scroll repeat 0% 0% } #content .left .first { PADDING-TOP: 0px } #content .left INPUT.hasDatepicker { BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-TOP: = medium none; BORDER-RIGHT: medium none } #content .left .datepickerContainer { DISPLAY: inline } #content .left .datepickerContainer IMG { DISPLAY: inline } #content .left .datepickerContainer { POSITION: relative; TOP: 4px; LEFT: -5px } BODY.toc #content { BORDER-RIGHT: #ccc 1px solid } .threeColumn#content .center .prevNext { BORDER-BOTTOM: #ccc 1px solid; PADDING-LEFT: 0px; HEIGHT: 15px; COLOR: = #999999; FONT-SIZE: 0.7em } .threeColumn#content .center .prevNext A { COLOR: #333333 } .threeColumn#content .center .prevNext DIV.prev { FLOAT: left } .threeColumn#content .center .prevNext DIV.next { FLOAT: right } .threeColumn#content .center .prevNext DIV.prev SPAN.arrow { PADDING-LEFT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/greyLeft= Arrow.gif) no-repeat left center; COLOR: #999999 } .threeColumn#content .center .prevNext DIV.prev SPAN.arrowActive { PADDING-LEFT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blackLef= tArrow.gif) no-repeat left center; FONT-WEIGHT: bold } .threeColumn#content .center .prevNext DIV.next SPAN.arrow { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/greyRigh= tArrow.gif) no-repeat right center; COLOR: #999999 } .threeColumn#content .center .prevNext DIV.next SPAN.arrowActive { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blackRig= htArrow.gif) no-repeat right center; FONT-WEIGHT: bold } .threeColumn#content .center .issueMeta { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 15px } .threeColumn#content .center .issueMeta H3 { PADDING-BOTTOM: 0px; TEXT-TRANSFORM: uppercase; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT: bold 0.7em "times new roman"; PADDING-TOP: 0px } .threeColumn#content .center .issueMeta H2 { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = FONT-FAMILY: times New Roman; LETTER-SPACING: -0.02em; FONT-SIZE: 1.6em; = PADDING-TOP: 10px } .threeColumn#content .center .issueMeta P { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .threeColumn#content .center .archiveBadge { PADDING-BOTTOM: 15px } .threeColumn#content .center .archiveBadge IMG { MARGIN: 0px auto } .threeColumn#content .center .audio { MARGIN: 0px 0px 30px; FONT-SIZE: 0.9em } .threeColumn#content .center .audio UL { MARGIN: 0px; FONT-SIZE: 0.75em } #content .center .tocContent { CLEAR: both; BORDER-TOP: #ccc 1px solid; PADDING-TOP: 15px } #content .tocContent .pages { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 10px; FLOAT: = right; COLOR: #333333; FONT-SIZE: 0.58em; PADDING-TOP: 3px } #content .tocContent .articleGrouping { BORDER-BOTTOM: #ccc 1px dotted; PADDING-BOTTOM: 5px; MARGIN: 0px 0px = 15px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; PADDING-TOP: 0px } .threeColumn#content .center .issuesPages { BORDER-BOTTOM: #ccc 1px solid; HEIGHT: 15px; FONT-SIZE: 0.7em } #content .tocContent .articleGrouping .articleType { PADDING-LEFT: 10px } #content .center .tocTop { MARGIN-LEFT: 10px } .threeColumn#content .center .issuesPages DIV.issues { FLOAT: left; FONT-WEIGHT: bold } .threeColumn#content .center .issuesPages DIV.pages { FLOAT: right } .threeColumn#content .center UL.foundIssues { MARGIN: 15px 0px 0px } .threeColumn#content .center UL.foundIssues LI { BORDER-BOTTOM: #ccc 1px dotted; PADDING-BOTTOM: 5px; LIST-STYLE-TYPE: = none; MARGIN: 0px 0px 15px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = FONT-SIZE: 0.7em; PADDING-TOP: 0px } .threeColumn#content .articleEntry { BORDER-BOTTOM: #fff 1px solid; BORDER-LEFT: #fff 1px solid; = PADDING-BOTTOM: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: 0px; = MARGIN-BOTTOM: 10px; BORDER-TOP: #fff 1px solid; BORDER-RIGHT: #fff 1px = solid; PADDING-TOP: 5px } .threeColumn#content .tocContent .articleEntry { CLEAR: right } .threeColumn#content .hover .tl { LINE-HEIGHT: 0 } .threeColumn#content .hover .bl { LINE-HEIGHT: 0 } .threeColumn#content .hover .pages { =09 } .threeColumn#content .hoverActive { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .threeColumn#content .hoverActive .pages { PADDING-BOTTOM: 3px; PADDING-LEFT: 3px; PADDING-RIGHT: 3px; = PADDING-TOP: 3px } .threeColumn#content .hoverActive .r { PADDING-RIGHT: 6px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/shadowri= ght.png) no-repeat right top } .threeColumn#content .hoverActive .topRow { DISPLAY: none } .threeColumn#content .hoverActive .b { BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/shadowbo= ttom.png) no-repeat left bottom; HEIGHT: 8px } .threeColumn#content .hoverActive .b { LINE-HEIGHT: 8px } .threeColumn#content .hoverActive .br { PADDING-RIGHT: 6px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/shadowbo= ttomright.png) no-repeat right bottom } .threeColumn#content .hoverActive .br { BACKGROUND-POSITION: right top } .threeColumn#content .hoverActive .content { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 4px; BACKGROUND-COLOR: #fefced; PADDING-LEFT: 9px; = PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px solid; BORDER-RIGHT: #ccc 1px = solid; PADDING-TOP: 4px } .threeColumn#content .hoverActive .wrap { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .threeColumn#content .center .hoverwrap { DISPLAY: none } .threeColumn#content .center .hoverwrap .hover_text { BORDER-BOTTOM: #ccc 1px dotted; MARGIN-BOTTOM: 5px; MARGIN-RIGHT: 10px } .threeColumn#content .center .hoverwrap .hover_text P { PADDING-BOTTOM: 8px; LINE-HEIGHT: 1.4em; MARGIN: 5px 0px 0px; = FONT-SIZE: 0.7em } .threeColumn#content .center .hoverwrap .pdf_save LI { PADDING-BOTTOM: 0px; PADDING-LEFT: 15px; PADDING-RIGHT: 0px; = BACKGROUND-REPEAT: no-repeat; FLOAT: right; HEIGHT: 12px; CLEAR: none; = FONT-SIZE: 0.62em; MARGIN-RIGHT: 10px; PADDING-TOP: 0px } .threeColumn#content .center .hoverwrap .pdf_save LI.lastChild { PADDING-RIGHT: 5px; MARGIN-RIGHT: 5px; BORDER-RIGHT: #ccc 1px solid } .threeColumn#content .center .hoverwrap .pdf_save UL { TEXT-ALIGN: right; WIDTH: 100%; OVERFLOW: hidden } .browseIssues #content .center .archiveBadge IMG { DISPLAY: block; MARGIN-LEFT: auto; MARGIN-RIGHT: auto } .browseIssues #content .center H2 { TEXT-ALIGN: left; MARGIN: 0px 0px 20px; FONT-SIZE: 1.1em; FONT-WEIGHT: = bold } .browseIssues #content .center .leftMonths { WIDTH: 200px; FLOAT: left; MARGIN-RIGHT: 10px } .browseIssues #content .center .rightMonths { FLOAT: left } .browseIssues #content .center .foundIssuesByYear { FONT-SIZE: 0.75em } .browseIssues #content .center .foundIssuesByYear DD { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .browseIssues #content .center .foundIssuesByYear DL { PADDING-BOTTOM: 15px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .browseIssues #content .center .foundIssuesByYear DT { PADDING-BOTTOM: 8px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; COLOR: = #676767; FONT-SIZE: 1.1em; FONT-WEIGHT: bold; PADDING-TOP: 0px } .browseIssues #content .center .welcomeMessage { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 15px; BACKGROUND-COLOR: #ebf3f6; PADDING-LEFT: 15px; = PADDING-RIGHT: 15px; MARGIN-BOTTOM: 15px; BORDER-TOP: #ccc 1px solid; = BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 15px } .browseIssues #content .center .welcomeMessage H2 { TEXT-ALIGN: center; TEXT-TRANSFORM: uppercase; MARGIN: 0px 0px 5px; = FONT-SIZE: 0.8em } .browseIssues #content .center .medicalIndexAllYears DL DT { FLOAT: left } .browseIssues #content .center .medicalIndexAllYears DL DD { FLOAT: left } .browseIssues #content .center .medicalIndexAllYears DL { WIDTH: 428px; MARGIN-BOTTOM: 15px; FONT-SIZE: 0.7em; OVERFLOW: hidden } .browseIssues #content .center .medicalIndexAllYears .archiveBadge { MARGIN: 30px 0px 5px } .browseIssues #content .center .medicalIndexAllYears DL DD { WIDTH: 38px } .browseIssues #content .center .medicalIndexAllYears DL DT { WIDTH: 35px; COLOR: #686868; FONT-SIZE: 1em; FONT-WEIGHT: bold } #ui-datepicker-div { FONT-SIZE: 0.7em } BUTTON.ui-datepicker-trigger { BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; PADDING-BOTTOM: = 0px; BACKGROUND-COLOR: #fff; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = BORDER-TOP: medium none; BORDER-RIGHT: medium none; PADDING-TOP: 0px } #toolsBox { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 8px; MARGIN: 0px 0px 0px 15px; PADDING-LEFT: 15px; = WIDTH: 269px; PADDING-RIGHT: 15px; BACKGROUND: #fdfce7; OVERFLOW: = hidden; BORDER-TOP: #ccc 1px solid; BORDER-RIGHT: #ccc 1px solid; = PADDING-TOP: 15px } #toolsBox H3 { PADDING-BOTTOM: 15px; TEXT-TRANSFORM: uppercase; FONT: bold 0.68em = "times new roman" } #toolsBox UL { WIDTH: 108px; MARGIN-BOTTOM: 15px; FLOAT: left; FONT-SIZE: 0.62em } #toolsBox LI { PADDING-BOTTOM: 4px; PADDING-LEFT: 16px; PADDING-RIGHT: 2px; = BACKGROUND: no-repeat left 2px; BORDER-TOP: #ccc 1px dotted; = PADDING-TOP: 4px } #toolsBox LI.lastChild { BORDER-BOTTOM: #ccc 1px dotted } #toolsBox LI.title { BACKGROUND: none transparent scroll repeat 0% 0%; PADDING-TOP: 10px } #toolsBox LI.sendToMobile { BORDER-BOTTOM: #ccc 1px dotted } #toolsBox UL.firstGroup { PADDING-RIGHT: 15px; MARGIN-RIGHT: 15px; BORDER-RIGHT: #ccc 1px solid } #toolsBox UL.secondGroup { WIDTH: 128px } #main .bottomAd { TEXT-ALIGN: right; PADDING-LEFT: 8px; BACKGROUND: #fff; CLEAR: both } #main .bottomAd P { PADDING-BOTTOM: 0px; BACKGROUND: none transparent scroll repeat 0% 0%; = FONT-SIZE: 0.62em } #main .toolsAd .bottomAd { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 8px; = PADDING-TOP: 8px } #main .toolsAd .bottomAd .ad .MicroTools { PADDING-LEFT: 68px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/toolsSpo= nsoredByLogo.gif) no-repeat left top; FLOAT: right } #main .toolsAd { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; WIDTH: = 299px; HEIGHT: 45px; MARGIN-LEFT: 15px; BORDER-TOP: 0px; BORDER-RIGHT: = #ccc 1px solid } #main .right LI { PADDING-BOTTOM: 4px; PADDING-LEFT: 16px; PADDING-RIGHT: 8px; = BACKGROUND: no-repeat left 3px; FLOAT: right; FONT-SIZE: 0.9em; = PADDING-TOP: 4px } #main:after { DISPLAY: block; HEIGHT: 0px; VISIBILITY: hidden; CLEAR: both; CONTENT: = '.' } .home #main #rightRail .imageChallengeSponsoredBy { COLOR: #aaa } BODY.imageChallenge #rightRail .MicroTrends { PADDING-BOTTOM: 0px; PADDING-LEFT: 150px; PADDING-RIGHT: 0px; = BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/icSponso= redBy_1line.gif) no-repeat left top; FLOAT: right; PADDING-TOP: 0px } BODY.imageChallenge #rightRail .MicroIMG { PADDING-BOTTOM: 0px; PADDING-LEFT: 150px; PADDING-RIGHT: 0px; = BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/icSponso= redBy_1line.gif) no-repeat left top; FLOAT: right; PADDING-TOP: 0px } .imageBoxICContainer .MicroTrends { PADDING-BOTTOM: 0px; PADDING-LEFT: 90px; PADDING-RIGHT: 0px; = BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/icSponso= redBy.gif) no-repeat left top; FLOAT: right; PADDING-TOP: 0px } .imageBoxICContainer .MicroIMG { PADDING-BOTTOM: 0px; PADDING-LEFT: 90px; PADDING-RIGHT: 0px; = BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/icSponso= redBy.gif) no-repeat left top; FLOAT: right; PADDING-TOP: 0px } .downloadPDF { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/pdfIcon.= gif) !important } .articleFullText { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/pdfIcon.= gif) !important } .printPage { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/printIco= n.gif) !important } .downloadSlides { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/download= SlidesIcon.gif) !important } .downloadCitation { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/download= CitationIcon.gif) !important } .listenToAudio { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/listenIc= on.gif) !important } .downloadAudio { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/download= AudioIcon.gif) !important } .emailPage { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/emailIco= n.gif) !important } .savePage { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/saveIcon= .gif) !important } .getAlert { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/alertIco= n.gif) !important } .sendToMobile { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/mobileIc= on.gif) !important } .getCME { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/cmeIcon.= gif) !important } .submitLetter { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/submitLe= tterIcon.gif) !important } .rssLink { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/rssIcon.= gif) !important } .reprints { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/icon_rep= rints.gif) !important } .articleContentIcons UL { OVERFLOW: hidden } .search .searchResults LI .articleContentIcons UL LI { PADDING-BOTTOM: 5px; LINE-HEIGHT: 1.1em; PADDING-LEFT: 15px; = PADDING-RIGHT: 5px; FLOAT: left; CLEAR: none; FONT-SIZE: 0.62em; = MARGIN-RIGHT: 5px; BORDER-RIGHT: #cccccc 1px solid; PADDING-TOP: 0px } .articleContentIcons UL LI { PADDING-BOTTOM: 5px; LINE-HEIGHT: 1.1em; PADDING-LEFT: 15px; = PADDING-RIGHT: 5px; FLOAT: left; CLEAR: none; FONT-SIZE: 0.62em; = MARGIN-RIGHT: 5px; BORDER-RIGHT: #cccccc 1px solid; PADDING-TOP: 0px } .audioIcon { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/listenIc= on.gif); BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left top } .videoIcon { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/icon_vid= eo.gif); BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left top } .interactiveIcon { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/icon_int= eractive.gif); BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left = top } .slideshowIcon { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/download= SlidesIcon.gif); BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left = top } .search .searchResults LI .articleContentIcons UL LI.freeIcon { PADDING-LEFT: 0px } .articleContentIcons UL LI.freeIcon { PADDING-LEFT: 0px } .search .searchResults LI .articleContentIcons UL LI.lastChild { BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-TOP: = medium none; BORDER-RIGHT: medium none } .articleContentIcons UL LI.lastChild { BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; BORDER-TOP: = medium none; BORDER-RIGHT: medium none } .indicator { POSITION: relative; TOP: 4px; LEFT: 8px } .indicator IMG { DISPLAY: inline } .discussionIcon { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/icon_com= ment.gif); BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left top } .pollIcon { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/icon_pol= l.gif); BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left top } .cmeIcon { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/cmeIcon.= gif); BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: left top } .freeIcon SPAN { COLOR: #ff3300 } #toolsLayer { POSITION: relative; PADDING-BOTTOM: 46px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-SIZE: 0.75em; OVERFLOW: visible; PADDING-TOP: = 0px } #toolsLayer H2 { LINE-HEIGHT: 1.2em; MARGIN: 0px 0px 5px; FONT-SIZE: 1.4em; FONT-WEIGHT: = bold } #toolsLayer .header { MARGIN: 0px 0px 20px } #toolsLayer .instructions { PADDING-BOTTOM: 0px; LINE-HEIGHT: normal; FONT-STYLE: italic; = FONT-SIZE: 0.9em; PADDING-TOP: 2px } #toolsLayer .formLine { MARGIN: 0px; CLEAR: both } #toolsLayer .formLineSubmit { TEXT-ALIGN: right; MARGIN: 0px 0px 10px } #toolsLayer .formLine LABEL { MARGIN: 10px 0px 3px; DISPLAY: block; FONT-WEIGHT: bold } #toolsLayer .formLine INPUT { WIDTH: 331px } #toolsLayer .formLine TEXTAREA { WIDTH: 331px } #toolsLayer SPAN.moreLink A { FONT-SIZE: 1.25em } #toolsLayer P { MARGIN: 4px 0px; WIDTH: 370px } #toolsLayer STRONG { FONT-WEIGHT: bold } #toolsLayer .alertMessage { PADDING-BOTTOM: 2px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; COLOR: red; = FONT-WEIGHT: bold; PADDING-TOP: 2px } #toolsLayer UL LI.toolHead { BORDER-BOTTOM: #ccc 1px dotted; FONT-WEIGHT: bold } #toolsLayer .downloadCitation { BACKGROUND: no-repeat } #toolsLayer UL { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } #toolsLayer UL LI { PADDING-BOTTOM: 0px; PADDING-LEFT: 20px; PADDING-RIGHT: 0px; = PADDING-TOP: 10px } #toolsLayer UL LI.toolHead { PADDING-BOTTOM: 5px; PADDING-LEFT: 20px; PADDING-RIGHT: 0px; = FONT-WEIGHT: normal; PADDING-TOP: 0px } #toolsLayer P.smallNote { FONT-STYLE: italic; COLOR: #333333 } #toolsLayer .yourEmail { PADDING-BOTTOM: 12px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 1.1em; PADDING-TOP: 8px } #toolsLayer .yourEmail .emailAddress { COLOR: #006892 } #toolsLayer .captchaNote { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 1.1em; PADDING-TOP: 0px } #toolsLayer #nejmCaptcha { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = MARGIN-LEFT: 22px; PADDING-TOP: 10px } #toolsLayer .eafConfirm .breadCrumb { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; WIDTH: 380px; PADDING-RIGHT: = 0px; FONT-SIZE: 1.2em; PADDING-TOP: 10px } #toolsLayer .eafConfirm .header { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 5px } #toolsLayer .eafConfirm .header .thankYou { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 1.2em; FONT-WEIGHT: bold; PADDING-TOP: 10px } #toolsLayer .eafConfirm .emailSentTo { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 1.1em; PADDING-TOP: 0px } #toolsLayer .eafConfirm .emailSentTo P { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 1.1em; PADDING-TOP: 5px } #toolsLayer .eafConfirm A.close { FONT-SIZE: 1.2em } #toolsLayer #eaf .formLine { MARGIN: 0px } #toolsLayer .articleAlert P { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 1em; PADDING-TOP: 5px } #toolsLayer .articleAlert .alertMessage { PADDING-BOTTOM: 2px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; COLOR: = #ff3300; FONT-SIZE: 1.2em; FONT-WEIGHT: bold; PADDING-TOP: 2px } #toolsLayer .toolsAd .bottomAd { TEXT-ALIGN: right; PADDING-LEFT: 8px; BACKGROUND: none transparent = scroll repeat 0% 0%; CLEAR: both } #toolsLayer .toolsAd .bottomAd { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 8px; = PADDING-TOP: 8px } #toolsLayer .toolsAd .bottomAd .ad { PADDING-LEFT: 68px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/toolsSpo= nsoredByLogo.gif) no-repeat left top; FLOAT: right } #toolsLayer .toolsAd { BORDER-BOTTOM: #ccc 1px solid; POSITION: absolute; BORDER-LEFT: #ccc = 1px solid; BACKGROUND-COLOR: #fff; PADDING-LEFT: 30px; WIDTH: 100%; = BOTTOM: -1px; HEIGHT: 45px; BORDER-TOP: #ccc 1px solid; BORDER-RIGHT: = #ccc 1px solid; LEFT: -16px; _bottom: 24px } #related { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; MARGIN: = 15px 0px 15px 15px; BORDER-TOP: #ccc 1px solid; BORDER-RIGHT: #ccc 1px = solid } #ie6 #related { HEIGHT: 1px } #ie7 #related { OVERFLOW: auto } #related #alsoSee { BORDER-BOTTOM: #ccc 1px solid; PADDING-BOTTOM: 15px; PADDING-LEFT: = 15px; PADDING-RIGHT: 15px; PADDING-TOP: 15px } #related #relatedContent { BORDER-BOTTOM: #ccc 1px solid; PADDING-BOTTOM: 15px; PADDING-LEFT: = 15px; PADDING-RIGHT: 15px; PADDING-TOP: 15px } #related #relatedContent { PADDING-BOTTOM: 8px } #related H3 { PADDING-BOTTOM: 15px; TEXT-TRANSFORM: uppercase; FONT: bold 0.68em = "times new roman" } #related #alsoSee LI { BORDER-BOTTOM: #ccc 1px dotted; PADDING-BOTTOM: 8px; MARGIN-BOTTOM: 8px } #related #relatedContent LI { BORDER-BOTTOM: #ccc 1px dotted; PADDING-BOTTOM: 8px; MARGIN-BOTTOM: 8px } #related .perspective#alsoSee LI .articleThumb { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 1px; MARGIN: 0px 0px 10px; PADDING-LEFT: 1px; WIDTH: = 75px; PADDING-RIGHT: 1px; FLOAT: right; BORDER-TOP: #ccc 1px solid; = BORDER-RIGHT: #ccc 1px solid; PADDING-TOP: 1px } #related .perspective#alsoSee LI { PADDING-BOTTOM: 10px; MARGIN-BOTTOM: 10px; CLEAR: both } #related #alsoSee LI.lastChild { BORDER-BOTTOM: 0px; PADDING-BOTTOM: 0px; MARGIN-BOTTOM: 0px } #related #relatedContent LI.lastChild { BORDER-BOTTOM: 0px; PADDING-BOTTOM: 0px; MARGIN-BOTTOM: 0px } #related LI P { FONT-SIZE: 0.62em } #related LI P.articleType { TEXT-TRANSFORM: uppercase; COLOR: #f30; FONT-SIZE: 0.58em } #related LI P.articleLink { PADDING-BOTTOM: 0.15em; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT: = 0.9em "times new roman"; PADDING-TOP: 0.15em } #related LI P.articleLink A { COLOR: #333 } #related LI P.articleDate { COLOR: #666 } #related P.moreRelatedArticles { TEXT-ALIGN: right; FONT-SIZE: 0.7em } #related P.moreRelatedArticles A { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blueRigh= tArrow.gif) no-repeat right center; FONT-WEIGHT: bold } #related #topics { PADDING-BOTTOM: 14px; PADDING-LEFT: 14px; WIDTH: 120px; PADDING-RIGHT: = 14px; FLOAT: left; PADDING-TOP: 14px } #related #moreIn { PADDING-BOTTOM: 14px; PADDING-LEFT: 14px; WIDTH: 120px; PADDING-RIGHT: = 14px; FLOAT: left; PADDING-TOP: 14px } #related .wide#moreIn { WIDTH: auto; FLOAT: none } #related #topics { BORDER-RIGHT: #ccc 1px solid } #related:after { DISPLAY: block; HEIGHT: 0px; VISIBILITY: hidden; CLEAR: both; CONTENT: = '.' } #related #topics H3 { PADDING-BOTTOM: 8px } #related #moreIn H3 { PADDING-BOTTOM: 8px } #related #searches H3 { PADDING-BOTTOM: 8px } #related #topics A { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blueRigh= tArrow.gif) no-repeat right center; FONT-SIZE: 0.7em; FONT-WEIGHT: bold } #related #moreIn A { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blueRigh= tArrow.gif) no-repeat right center; FONT-SIZE: 0.7em; FONT-WEIGHT: bold } #related #searches A { PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/blueRigh= tArrow.gif) no-repeat right center; FONT-SIZE: 0.7em; FONT-WEIGHT: bold } #related #searches { PADDING-BOTTOM: 15px; PADDING-LEFT: 15px; PADDING-RIGHT: 15px; = PADDING-TOP: 15px } #related #searches A { BACKGROUND: none transparent scroll repeat 0% 0%; FONT-WEIGHT: normal } #rightRailAd { MARGIN: 0px 0px 15px; BACKGROUND: none transparent scroll repeat 0% 0% } #ie6 #rightRailAd { HEIGHT: 1px } #rightRailAd .bannerAd { MARGIN: 0px auto; WIDTH: 300px } #rightRailAd .bannerAdTower { TEXT-ALIGN: center } #rightRailAd .bannerAd .inner { PADDING-BOTTOM: 0px; PADDING-LEFT: 15px; PADDING-RIGHT: 0px; = PADDING-TOP: 15px } #rightRailAd .bannerAdTower .rightTower { PADDING-BOTTOM: 0px; PADDING-LEFT: 15px; PADDING-RIGHT: 0px; = PADDING-TOP: 15px } #rightRailAd .bannerAd .inner { BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/horizont= alAd.gif) no-repeat center 4px } #rightRailAd .rightTower { DISPLAY: inline-block; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/horizont= alAd.gif) no-repeat center 4px } #ie6 #rightRailAd .rightTower { DISPLAY: inline } #ie7 #rightRailAd .rightTower { DISPLAY: inline } #rightRail .bottomBox { PADDING-BOTTOM: 15px; PADDING-LEFT: 15px; PADDING-RIGHT: 0px; = PADDING-TOP: 15px } #rightRail .boxContent { PADDING-BOTTOM: 15px; PADDING-LEFT: 15px; PADDING-RIGHT: 0px; = PADDING-TOP: 15px } #rightRail .boxContent H3 { PADDING-BOTTOM: 12px; TEXT-TRANSFORM: uppercase; FONT: bold 0.7em = "times new roman" } .rightRailBannerAd { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = MARGIN-BOTTOM: 15px; BORDER-TOP: #ccc 1px solid; BORDER-RIGHT: #ccc 1px = solid } .trends #rightRail .bottomAd { MARGIN: 15px 0px 0px } #trendsBox { BORDER-BOTTOM: #ccc 1px solid; BORDER-LEFT: #ccc 1px solid; = PADDING-BOTTOM: 3px; MARGIN: 15px 0px 0px 15px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; BORDER-TOP: #ccc 1px solid; BORDER-RIGHT: #ccc 1px = solid; PADDING-TOP: 15px } #trendsBox H3 { PADDING-BOTTOM: 12px; TEXT-TRANSFORM: uppercase; PADDING-LEFT: 15px; = PADDING-RIGHT: 15px; FONT: bold 0.68em "times new roman"; PADDING-TOP: = 0px } #trendsBox H3 SPAN { TEXT-TRANSFORM: none; FONT: 0.9em arial } #trendsBox UL { PADDING-BOTTOM: 0px; PADDING-LEFT: 15px; PADDING-RIGHT: 15px; = MARGIN-BOTTOM: 0px; PADDING-TOP: 0px } #trendsBox LI { PADDING-BOTTOM: 0px; PADDING-LEFT: 2px; PADDING-RIGHT: 2px; = PADDING-TOP: 0px } #trendsBox LI P { FONT-SIZE: 0.62em } #trendsBox LI P.articleDate { PADDING-BOTTOM: 8px; COLOR: #666 } #trendsBox LI P.articleImage { FLOAT: left; MARGIN-RIGHT: 8px } #trendsBox LI P.articleImage A { MARGIN: 2px 0px; FLOAT: left } #trendsBox LI P.articleLink { PADDING-BOTTOM: 0.15em; PADDING-LEFT: 0px; 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BORDER-RIGHT: medium = none } .nejmSiteEditable .colLayout DL { PADDING-BOTTOM: 20px } .mceContentBody .colLayout DL { PADDING-BOTTOM: 20px } .nejmSiteEditable .colLayoutNoBorder DL { PADDING-BOTTOM: 20px } .mceContentBody .colLayoutNoBorder DL { PADDING-BOTTOM: 20px } .nejmSiteEditable .colLayout DT { PADDING-BOTTOM: 4px; TEXT-TRANSFORM: uppercase; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-WEIGHT: bold; PADDING-TOP: 0px } .mceContentBody .colLayout DT { PADDING-BOTTOM: 4px; TEXT-TRANSFORM: uppercase; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-WEIGHT: bold; PADDING-TOP: 0px } .nejmSiteEditable .colLayoutNoBorder DT { PADDING-BOTTOM: 4px; TEXT-TRANSFORM: uppercase; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-WEIGHT: bold; PADDING-TOP: 0px } .mceContentBody .colLayoutNoBorder DT { PADDING-BOTTOM: 4px; TEXT-TRANSFORM: uppercase; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-WEIGHT: bold; PADDING-TOP: 0px } .nejmSiteEditable .colLayout DD { PADDING-BOTTOM: 4px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .mceContentBody .colLayout DD { PADDING-BOTTOM: 4px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .nejmSiteEditable .colLayoutNoBorder DD { PADDING-BOTTOM: 4px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .mceContentBody .colLayoutNoBorder DD { PADDING-BOTTOM: 4px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .nejmSiteEditable { PADDING-BOTTOM: 30px } .mceContentBody { PADDING-BOTTOM: 30px } .nejmSiteEditable DIV.multicolLayout { PADDING-BOTTOM: 20px; WIDTH: 100%; OVERFLOW: auto } .nejmSiteEditable DIV.cols25 { PADDING-BOTTOM: 20px; WIDTH: 24%; FLOAT: left } .mceContentBody DIV.cols25 { PADDING-BOTTOM: 20px; WIDTH: 24%; FLOAT: left } .nejmSiteEditable DIV.cols33 { PADDING-BOTTOM: 20px; WIDTH: 32%; FLOAT: left } .mceContentBody DIV.cols33 { PADDING-BOTTOM: 20px; WIDTH: 32%; FLOAT: left } .nejmSiteEditable #main DIV.cols25 UL { LIST-STYLE-TYPE: none; PADDING-RIGHT: 15px; MARGIN-LEFT: 0px; = LIST-STYLE-IMAGE: none } .nejmSiteEditable #main DIV.cols33 UL { LIST-STYLE-TYPE: none; PADDING-RIGHT: 15px; MARGIN-LEFT: 0px; = LIST-STYLE-IMAGE: none } .mceContentBody #main DIV.cols25 UL { LIST-STYLE-TYPE: none; PADDING-RIGHT: 15px; MARGIN-LEFT: 0px; = LIST-STYLE-IMAGE: none } .mceContentBody #main DIV.cols33 UL { LIST-STYLE-TYPE: none; PADDING-RIGHT: 15px; MARGIN-LEFT: 0px; = LIST-STYLE-IMAGE: none } .nejmSiteEditable #main DIV.cols25 UL.last { LIST-STYLE-TYPE: none; PADDING-RIGHT: 0px; MARGIN-LEFT: 0px; = LIST-STYLE-IMAGE: none } .nejmSiteEditable #main DIV.cols33 UL.last { LIST-STYLE-TYPE: none; PADDING-RIGHT: 0px; MARGIN-LEFT: 0px; = LIST-STYLE-IMAGE: none } .mceContentBody #main DIV.cols25 UL.last { LIST-STYLE-TYPE: none; PADDING-RIGHT: 0px; MARGIN-LEFT: 0px; = LIST-STYLE-IMAGE: none } .mceContentBody #main DIV.cols33 UL.last { LIST-STYLE-TYPE: none; PADDING-RIGHT: 0px; MARGIN-LEFT: 0px; = LIST-STYLE-IMAGE: none } .nejmSiteEditable H2 { LINE-HEIGHT: 1.25em; FONT-FAMILY: Arial, Helvetica, sans-serif; = FONT-SIZE: 1.12em } .mceContentBody H2 { LINE-HEIGHT: 1.25em; FONT-FAMILY: Arial, Helvetica, sans-serif; = FONT-SIZE: 1.12em } .nejmSiteEditable H3 { PADDING-BOTTOM: 4px; LINE-HEIGHT: 1.4em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-SIZE: 0.87em; PADDING-TOP: 15px } .mceContentBody H3 { PADDING-BOTTOM: 4px; LINE-HEIGHT: 1.4em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-SIZE: 0.87em; PADDING-TOP: 15px } .nejmSiteEditable H2.first { PADDING-TOP: 0px } .nejmSiteEditable H2.feat { PADDING-TOP: 0px } .nejmSiteEditable .text H2 { PADDING-TOP: 0px } .nejmSiteEditable .text H3 { PADDING-TOP: 0px } .nejmSiteEditable .textforImageLg H3 { PADDING-TOP: 0px } .mceContentBody H2.first { PADDING-TOP: 0px } .mceContentBody H2.feat { PADDING-TOP: 0px } .mceContentBody .text H2 { PADDING-TOP: 0px } .mceContentBody .text H3 { PADDING-TOP: 0px } .mceContentBody .textforImageLg H3 { PADDING-TOP: 0px } .nejmSiteEditable H2 SPAN { FONT-WEIGHT: normal } .nejmSiteEditable H3 SPAN { FONT-WEIGHT: normal } .mceContentBody H2 SPAN { FONT-WEIGHT: normal } .mceContentBody H3 SPAN { FONT-WEIGHT: normal } .nejmSiteEditable H2 SPAN { FONT-SIZE: 0.87em } .mceContentBody H2 SPAN { FONT-SIZE: 0.87em } .nejmSiteEditable H4 { PADDING-BOTTOM: 4px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = FONT-FAMILY: Arial, Helvetica, sans-serif; FONT-SIZE: 0.81em; = FONT-WEIGHT: bold; PADDING-TOP: 8px } .mceContentBody H4 { PADDING-BOTTOM: 4px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = FONT-FAMILY: Arial, Helvetica, sans-serif; FONT-SIZE: 0.81em; = FONT-WEIGHT: bold; PADDING-TOP: 8px } .nejmSiteEditable H5 { PADDING-BOTTOM: 4px; LINE-HEIGHT: 1.4em; FONT-SIZE: 0.75em } .mceContentBody H5 { PADDING-BOTTOM: 4px; LINE-HEIGHT: 1.4em; FONT-SIZE: 0.75em } .nejmSiteEditable H5.note { FONT-STYLE: normal; MARGIN-TOP: 10px } .mceContentBody H5.note { FONT-STYLE: normal; MARGIN-TOP: 10px } .nejmSiteEditable H5.faq { PADDING-TOP: 17px } .mceContentBody H5.faq { PADDING-TOP: 17px } .nejmSiteEditable UL.multiCol { LIST-STYLE-TYPE: none; FLOAT: left; LIST-STYLE-IMAGE: none } .mceContentBody UL.multiCol { LIST-STYLE-TYPE: none; FLOAT: left; LIST-STYLE-IMAGE: none } .nejmSiteEditable UL.multiCol LI { WIDTH: 203px; FLOAT: left } .mceContentBody UL.multiCol LI { WIDTH: 203px; FLOAT: left } .nejmSiteEditable UL.multiColDisc { FLOAT: left; MARGIN-LEFT: 40px } .mceContentBody UL.multiColDisc { FLOAT: left; MARGIN-LEFT: 40px } .nejmSiteEditable UL.multiColDisc LI { WIDTH: 203px; FLOAT: left } .mceContentBody UL.multiColDisc LI { WIDTH: 203px; FLOAT: left } .nejmSiteEditable .textforImageLg UL.multiCol { MARGIN: 0px; WIDTH: 100%; FLOAT: left } .mceContentBody .textforImageLg UL.multiCol { MARGIN: 0px; WIDTH: 100%; FLOAT: left } .nejmSiteEditable .textforImageLg UL.multiCol LI.disc { LIST-STYLE-TYPE: disc; WIDTH: 90px; FLOAT: left; MARGIN-LEFT: 20px } .mceContentBody .textforImageLg UL.multiCol LI.disc { LIST-STYLE-TYPE: disc; WIDTH: 90px; FLOAT: left; MARGIN-LEFT: 20px } .nejmSiteEditable 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{ BORDER-BOTTOM: #cccccc 1px solid; BORDER-LEFT: #cccccc 1px solid; = BORDER-TOP: #cccccc 1px solid; BORDER-RIGHT: #cccccc 1px solid } .mceContentBody .imageSm IMG { BORDER-BOTTOM: #cccccc 1px solid; BORDER-LEFT: #cccccc 1px solid; = BORDER-TOP: #cccccc 1px solid; BORDER-RIGHT: #cccccc 1px solid } .nejmSiteEditable .imageLg { FLOAT: left } .mceContentBody .imageLg { FLOAT: left } .nejmSiteEditable .imageLg IMG { BORDER-LEFT: #cccccc 1px solid } .mceContentBody .imageLg IMG { BORDER-LEFT: #cccccc 1px solid } .nejmSiteEditable .text { WIDTH: 443px; FLOAT: left } .mceContentBody .text { WIDTH: 443px; FLOAT: left } .nejmSiteEditable .textforImageLg { PADDING-BOTTOM: 15px; PADDING-LEFT: 15px; WIDTH: 210px; PADDING-RIGHT: = 15px; FLOAT: left; PADDING-TOP: 7px } .mceContentBody .textforImageLg { PADDING-BOTTOM: 15px; PADDING-LEFT: 15px; WIDTH: 210px; PADDING-RIGHT: = 15px; FLOAT: left; PADDING-TOP: 7px } .nejmSiteEditable .textFullWidth { WIDTH: 608px; FLOAT: left } .mceContentBody .textFullWidth { WIDTH: 608px; FLOAT: left } .nejmSiteEditable .button IMG { MARGIN: 0px; DISPLAY: inline; CLEAR: both } .mceContentBody .button IMG { MARGIN: 0px; DISPLAY: inline; CLEAR: both } .nejmSiteEditable .button IMG.btnSecond { PADDING-LEFT: 10px } .mceContentBody .button IMG.btnSecond { PADDING-LEFT: 10px } .nejmSiteEditable .video { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmVide= oSE.jpg) no-repeat 0px top; HEIGHT: 230px } .mceContentBody .video { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmVide= oSE.jpg) no-repeat 0px top; HEIGHT: 230px } .nejmSiteEditable .videoLink { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmVide= oSE.jpg) no-repeat 0px top; FLOAT: left; HEIGHT: 230px } .mceContentBody .videoLink { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmVide= oSE.jpg) no-repeat 0px top; FLOAT: left; HEIGHT: 230px } .nejmSiteEditable .videoLink:hover { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmVide= oSE.jpg) no-repeat -435px top; HEIGHT: 230px; TEXT-DECORATION: none } .mceContentBody .videoLink:hover { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmVide= oSE.jpg) no-repeat -435px top; HEIGHT: 230px; TEXT-DECORATION: none } .nejmSiteEditable .tour { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmTour= SE.jpg) no-repeat 0px top; HEIGHT: 240px } .mceContentBody .tour { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmTour= SE.jpg) no-repeat 0px top; HEIGHT: 240px } .nejmSiteEditable .tourLink { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmTour= SE.jpg) no-repeat 0px top; FLOAT: left; HEIGHT: 240px } .mceContentBody .tourLink { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmTour= SE.jpg) no-repeat 0px top; FLOAT: left; HEIGHT: 240px } .nejmSiteEditable .tourLink:hover { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmTour= SE.jpg) no-repeat -435px top; HEIGHT: 240px; TEXT-DECORATION: none } .mceContentBody .tourLink:hover { WIDTH: 435px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/nejmTour= SE.jpg) no-repeat -435px top; HEIGHT: 240px; TEXT-DECORATION: none } .modal-container { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/modal/mo= dal-bg.jpg); BORDER-BOTTOM: #ccc 4px solid; POSITION: absolute; = BORDER-LEFT: #ccc 4px solid; PADDING-BOTTOM: 0px; BACKGROUND-COLOR: = #eff1fe; PADDING-LEFT: 0px; WIDTH: 450px; PADDING-RIGHT: 0px; = BACKGROUND-REPEAT: no-repeat; BACKGROUND-POSITION: 199px 180px; HEIGHT: = 458px; MARGIN-LEFT: -225px; OVERFLOW: visible; BORDER-TOP: #ccc 4px = solid; TOP: 20%; BORDER-RIGHT: #ccc 4px solid; PADDING-TOP: 0px; LEFT: = 50%; -moz-box-shadow: 6px 6px 8px rgba(0, 0, 0, 0.17); = -webkit-box-shadow: 6px 6px 8px rgba(0, 0, 0, 0.17); box-shadow: 6px 6px = 8px rgba(0, 0, 0, 0.17) } .modal-container .close { TEXT-INDENT: -999em; MARGIN: 5px; WIDTH: 16px; DISPLAY: block; = BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/modal/bt= n-close.gif) no-repeat left top; FLOAT: right; HEIGHT: 16px; CURSOR: = pointer } .modal-container H1.logo { PADDING-BOTTOM: 0px; TEXT-INDENT: -999em; MARGIN: 0px 0px 5px 15px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/modal/ne= jm-logo.gif) no-repeat left top; CLEAR: right; PADDING-TOP: 0px } .modal-container .modal-content { PADDING-BOTTOM: 0px; PADDING-LEFT: 24px; PADDING-RIGHT: 24px; = PADDING-TOP: 0px } .modal-container .modal-content H2 { PADDING-BOTTOM: 0px; LINE-HEIGHT: 1.45; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-FAMILY: "Times New Roman", = Times, Georgia, serif; FONT-SIZE: 23px; FONT-WEIGHT: normal; = PADDING-TOP: 0px } .modal-container .modal-content P { PADDING-BOTTOM: 1.45em; LINE-HEIGHT: 1.45; MARGIN: 0px; FONT-FAMILY: = Arial, Helvetica, sans-serif; FONT-SIZE: 11px; FONT-WEIGHT: normal } .modal-container .modal-content UL { LIST-STYLE-POSITION: outside; PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: = disc; MARGIN: 0px 0px 1.3em 13px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .modal-container .modal-content UL LI { PADDING-BOTTOM: 0px; LINE-HEIGHT: 1.45; MARGIN: 0px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-FAMILY: Arial, Helvetica, sans-serif; = FONT-SIZE: 11px; FONT-WEIGHT: normal; PADDING-TOP: 0px } .modal-container .modal-content .btn-confirm-your-account A { TEXT-INDENT: -999em; WIDTH: 178px; DISPLAY: block; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/modal/bt= n-confirm-your-account.gif) no-repeat left top; HEIGHT: 30px; = MARGIN-LEFT: -3px } .modal-container .modal-content .create-an-account { PADDING-RIGHT: 8px; DISPLAY: inline-block; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/img/modal/ic= on-arrow.gif) no-repeat right 50% } .modal-container .modal-content A:link { COLOR: #006892; TEXT-DECORATION: none } .modal-container .modal-content A:visited { COLOR: #006892; TEXT-DECORATION: none } .modal-container .modal-content A:hover { TEXT-DECORATION: underline } #commentSearch .field { PADDING-BOTTOM: 0.5em; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; CLEAR: = both; FONT-SIZE: smaller; PADDING-TOP: 0.5em } #commentSearch LABEL { WIDTH: 12em; DISPLAY: block; FLOAT: left; FONT-WEIGHT: bold } #commentSearch LABEL.and { PADDING-BOTTOM: 0px; PADDING-LEFT: 0.5em; WIDTH: auto; PADDING-RIGHT: = 0.5em; PADDING-TOP: 0px } #commentSearch .text { WIDTH: 20em; FLOAT: left } #commentSearch .dateRange .text { WIDTH: 8em } #commentSearchResult { MARGIN: 1em 0px; FONT-SIZE: small } #commentSearchResult TABLE { WIDTH: 100% } #commentSearchResult THEAD { BACKGROUND-COLOR: #bbb; FONT-WEIGHT: bold } #commentSearchResult TH { BORDER-LEFT: #fff 1px solid; PADDING-BOTTOM: 0.2em; PADDING-LEFT: = 0.1em; PADDING-RIGHT: 0.1em; PADDING-TOP: 0.2em } #commentSearchResult TD { BORDER-LEFT: #fff 1px solid; PADDING-BOTTOM: 0.2em; PADDING-LEFT: = 0.1em; PADDING-RIGHT: 0.1em; PADDING-TOP: 0.2em } #commentSearchResult .odd { BACKGROUND-COLOR: #eee } #commentSearchResult .pagination { TEXT-ALIGN: right; MARGIN: 1em 0px } #commentSearchResult .separator:after { CONTENT: "|" } .comment { BORDER-BOTTOM: gray 1px dotted; PADDING-BOTTOM: 1em; PADDING-TOP: 1em } .moderatorContent { PADDING-BOTTOM: 0.5em; BACKGROUND-COLOR: #e1e1e1; PADDING-LEFT: 0.5em; = PADDING-RIGHT: 0.5em; PADDING-TOP: 0.5em } .commenterInfo { PADDING-BOTTOM: 1em; COLOR: #797979; FONT-SIZE: 0.7em } #content .discussion .pages { MARGIN-BOTTOM: 0px } #content .section .commentContent H3 { TEXT-TRANSFORM: none } #content .section .moderatorContent H3 { TEXT-TRANSFORM: none } .discussion .bottom { BORDER-BOTTOM: medium none } .commentForm { MARGIN-TOP: 1em; FONT-SIZE: 0.9em; BORDER-TOP: #cccccc 3px double } .commentForm H3 { MARGIN-TOP: 1em; PADDING-TOP: 1em } .commentForm A.more { FONT-SIZE: 0.75em } .commentForm .commentQuestion { FONT-SIZE: 0.75em } .commentForm FORM { PADDING-TOP: 1em } .article #content .commentForm #signInForm H2 { LINE-HEIGHT: 1.2em; MARGIN: 0px 0px 2px; FONT-SIZE: 0.87em; = FONT-WEIGHT: bold; PADDING-TOP: 0px } .article #content .commentForm .registrationInfo H2 { LINE-HEIGHT: 1.2em; MARGIN: 0px 0px 2px; FONT-SIZE: 0.87em; = FONT-WEIGHT: bold; PADDING-TOP: 0px } .commentForm #signInForm { MARGIN-TOP: 1em; FLOAT: left; BORDER-RIGHT: #ccc 1px solid } .commentForm FORM.layerForm { MARGIN-RIGHT: 1em; PADDING-TOP: 0px } .registrationInfo { WIDTH: 200px; FLOAT: 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PADDING-TOP: 1em } .commentForm .alertMessage { TEXT-ALIGN: center; PADDING-BOTTOM: 0.5em; LINE-HEIGHT: 1.2em; = MARGIN-TOP: 1em; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; COLOR: black; = FONT-SIZE: 0.8em; FONT-WEIGHT: bold; PADDING-TOP: 0.5em } .leftPager { FLOAT: left } .selected A { COLOR: black } .discussionModeration DL { MARGIN: 0.5em 0px 1em; FONT-SIZE: 0.7em } .discussionModeration DT { FONT-WEIGHT: bold } .discussionModeration DD { MARGIN-BOTTOM: 1em } .discussionModeration TEXTAREA { FONT-SIZE: 0.97em } .discussionModeration TEXTAREA[readonly] { BACKGROUND-COLOR: #eee } .discussionModeration .error { COLOR: red } .discussionModeration .success { COLOR: green } #CM8Test { POSITION: absolute; COLOR: red; TOP: 130px; FONT-WEIGHT: bold } .error { COLOR: red } #content DL.articleTabs #searchFilterContent DT { BORDER-BOTTOM: medium none; POSITION: static; BORDER-LEFT: medium none; = LINE-HEIGHT: normal; MARGIN: 1em 0px; FLOAT: none; FONT-SIZE: 1em; = BORDER-TOP: medium none; 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.ui-icon-arrowthick-1-s { BACKGROUND-POSITION: -64px -48px } .ui-icon-arrowthick-1-sw { BACKGROUND-POSITION: -80px -48px } .ui-icon-arrowthick-1-w { BACKGROUND-POSITION: -96px -48px } .ui-icon-arrowthick-1-nw { BACKGROUND-POSITION: -112px -48px } .ui-icon-arrowthick-2-n-s { BACKGROUND-POSITION: -128px -48px } .ui-icon-arrowthick-2-ne-sw { BACKGROUND-POSITION: -144px -48px } .ui-icon-arrowthick-2-e-w { BACKGROUND-POSITION: -160px -48px } .ui-icon-arrowthick-2-se-nw { BACKGROUND-POSITION: -176px -48px } .ui-icon-arrowthickstop-1-n { BACKGROUND-POSITION: -192px -48px } .ui-icon-arrowthickstop-1-e { BACKGROUND-POSITION: -208px -48px } .ui-icon-arrowthickstop-1-s { BACKGROUND-POSITION: -224px -48px } .ui-icon-arrowthickstop-1-w { BACKGROUND-POSITION: -240px -48px } .ui-icon-arrowreturnthick-1-w { BACKGROUND-POSITION: 0px -64px } .ui-icon-arrowreturnthick-1-n { BACKGROUND-POSITION: -16px -64px } .ui-icon-arrowreturnthick-1-e { BACKGROUND-POSITION: -32px -64px } .ui-icon-arrowreturnthick-1-s { BACKGROUND-POSITION: -48px -64px } .ui-icon-arrowreturn-1-w { BACKGROUND-POSITION: -64px -64px } .ui-icon-arrowreturn-1-n { BACKGROUND-POSITION: -80px -64px } .ui-icon-arrowreturn-1-e { BACKGROUND-POSITION: -96px -64px } .ui-icon-arrowreturn-1-s { BACKGROUND-POSITION: -112px -64px } .ui-icon-arrowrefresh-1-w { BACKGROUND-POSITION: -128px -64px } .ui-icon-arrowrefresh-1-n { BACKGROUND-POSITION: -144px -64px } .ui-icon-arrowrefresh-1-e { BACKGROUND-POSITION: -160px -64px } .ui-icon-arrowrefresh-1-s { BACKGROUND-POSITION: -176px -64px } .ui-icon-arrow-4 { BACKGROUND-POSITION: 0px -80px } .ui-icon-arrow-4-diag { BACKGROUND-POSITION: -16px -80px } .ui-icon-extlink { BACKGROUND-POSITION: -32px -80px } .ui-icon-newwin { BACKGROUND-POSITION: -48px -80px } .ui-icon-refresh { BACKGROUND-POSITION: -64px -80px } .ui-icon-shuffle { BACKGROUND-POSITION: -80px -80px } .ui-icon-transfer-e-w { BACKGROUND-POSITION: -96px -80px } .ui-icon-transferthick-e-w { BACKGROUND-POSITION: -112px -80px } .ui-icon-folder-collapsed { BACKGROUND-POSITION: 0px -96px } .ui-icon-folder-open { BACKGROUND-POSITION: -16px -96px } .ui-icon-document { BACKGROUND-POSITION: -32px -96px } .ui-icon-document-b { BACKGROUND-POSITION: -48px -96px } .ui-icon-note { BACKGROUND-POSITION: -64px -96px } .ui-icon-mail-closed { BACKGROUND-POSITION: -80px -96px } .ui-icon-mail-open { BACKGROUND-POSITION: -96px -96px } .ui-icon-suitcase { BACKGROUND-POSITION: -112px -96px } .ui-icon-comment { BACKGROUND-POSITION: -128px -96px } .ui-icon-person { BACKGROUND-POSITION: -144px -96px } .ui-icon-print { BACKGROUND-POSITION: -160px -96px } .ui-icon-trash { BACKGROUND-POSITION: -176px -96px } .ui-icon-locked { BACKGROUND-POSITION: -192px -96px } .ui-icon-unlocked { BACKGROUND-POSITION: -208px -96px } .ui-icon-bookmark { BACKGROUND-POSITION: -224px -96px } .ui-icon-tag { BACKGROUND-POSITION: -240px -96px } .ui-icon-home { BACKGROUND-POSITION: 0px -112px } .ui-icon-flag { BACKGROUND-POSITION: -16px -112px } .ui-icon-calendar { BACKGROUND-POSITION: -32px -112px } .ui-icon-cart { BACKGROUND-POSITION: -48px -112px } .ui-icon-pencil { BACKGROUND-POSITION: -64px -112px } .ui-icon-clock { BACKGROUND-POSITION: -80px -112px } .ui-icon-disk { BACKGROUND-POSITION: -96px -112px } .ui-icon-calculator { BACKGROUND-POSITION: -112px -112px } .ui-icon-zoomin { BACKGROUND-POSITION: -128px -112px } .ui-icon-zoomout { BACKGROUND-POSITION: -144px -112px } .ui-icon-search { BACKGROUND-POSITION: -160px -112px } .ui-icon-wrench { BACKGROUND-POSITION: -176px -112px } .ui-icon-gear { BACKGROUND-POSITION: -192px -112px } .ui-icon-heart { BACKGROUND-POSITION: -208px -112px } .ui-icon-star { BACKGROUND-POSITION: -224px -112px } .ui-icon-link { BACKGROUND-POSITION: -240px -112px } .ui-icon-cancel { BACKGROUND-POSITION: 0px -128px } .ui-icon-plus { BACKGROUND-POSITION: -16px -128px } .ui-icon-plusthick { BACKGROUND-POSITION: -32px -128px } .ui-icon-minus { BACKGROUND-POSITION: -48px -128px } .ui-icon-minusthick { BACKGROUND-POSITION: -64px -128px } .ui-icon-close { BACKGROUND-POSITION: -80px -128px } .ui-icon-closethick { BACKGROUND-POSITION: -96px -128px } .ui-icon-key { BACKGROUND-POSITION: -112px -128px } .ui-icon-lightbulb { BACKGROUND-POSITION: -128px -128px } .ui-icon-scissors { BACKGROUND-POSITION: -144px -128px } .ui-icon-clipboard { BACKGROUND-POSITION: -160px -128px } .ui-icon-copy { BACKGROUND-POSITION: -176px -128px } .ui-icon-contact { BACKGROUND-POSITION: -192px -128px } .ui-icon-image { BACKGROUND-POSITION: -208px -128px } .ui-icon-video { BACKGROUND-POSITION: -224px -128px } .ui-icon-script { BACKGROUND-POSITION: -240px -128px } .ui-icon-alert { BACKGROUND-POSITION: 0px -144px } .ui-icon-info { BACKGROUND-POSITION: -16px -144px } .ui-icon-notice { BACKGROUND-POSITION: -32px -144px } .ui-icon-help { BACKGROUND-POSITION: -48px -144px } .ui-icon-check { BACKGROUND-POSITION: -64px -144px } .ui-icon-bullet { BACKGROUND-POSITION: -80px -144px } .ui-icon-radio-off { BACKGROUND-POSITION: -96px -144px } .ui-icon-radio-on { BACKGROUND-POSITION: -112px -144px } .ui-icon-pin-w { BACKGROUND-POSITION: -128px -144px } .ui-icon-pin-s { BACKGROUND-POSITION: -144px -144px } .ui-icon-play { BACKGROUND-POSITION: 0px -160px } .ui-icon-pause { BACKGROUND-POSITION: -16px -160px } .ui-icon-seek-next { BACKGROUND-POSITION: -32px -160px } .ui-icon-seek-prev { BACKGROUND-POSITION: -48px -160px } .ui-icon-seek-end { BACKGROUND-POSITION: -64px -160px } .ui-icon-seek-first { BACKGROUND-POSITION: -80px -160px } .ui-icon-stop { BACKGROUND-POSITION: -96px -160px } .ui-icon-eject { BACKGROUND-POSITION: -112px -160px } .ui-icon-volume-off { BACKGROUND-POSITION: -128px -160px } .ui-icon-volume-on { BACKGROUND-POSITION: -144px -160px } .ui-icon-power { BACKGROUND-POSITION: 0px -176px } .ui-icon-signal-diag { BACKGROUND-POSITION: -16px -176px } .ui-icon-signal { BACKGROUND-POSITION: -32px -176px } .ui-icon-battery-0 { BACKGROUND-POSITION: -48px -176px } .ui-icon-battery-1 { BACKGROUND-POSITION: -64px -176px } .ui-icon-battery-2 { BACKGROUND-POSITION: -80px -176px } .ui-icon-battery-3 { BACKGROUND-POSITION: -96px -176px } .ui-icon-circle-plus { BACKGROUND-POSITION: 0px -192px } .ui-icon-circle-minus { BACKGROUND-POSITION: -16px -192px } .ui-icon-circle-close { BACKGROUND-POSITION: -32px -192px } .ui-icon-circle-triangle-e { BACKGROUND-POSITION: -48px -192px } .ui-icon-circle-triangle-s { BACKGROUND-POSITION: -64px -192px } .ui-icon-circle-triangle-w { BACKGROUND-POSITION: -80px -192px } .ui-icon-circle-triangle-n { BACKGROUND-POSITION: -96px -192px } .ui-icon-circle-arrow-e { BACKGROUND-POSITION: -112px -192px } .ui-icon-circle-arrow-s { BACKGROUND-POSITION: -128px -192px } .ui-icon-circle-arrow-w { BACKGROUND-POSITION: -144px -192px } .ui-icon-circle-arrow-n { BACKGROUND-POSITION: -160px -192px } .ui-icon-circle-zoomin { BACKGROUND-POSITION: -176px -192px } .ui-icon-circle-zoomout { BACKGROUND-POSITION: -192px -192px } .ui-icon-circle-check { BACKGROUND-POSITION: -208px -192px } .ui-icon-circlesmall-plus { BACKGROUND-POSITION: 0px -208px } .ui-icon-circlesmall-minus { BACKGROUND-POSITION: -16px -208px } .ui-icon-circlesmall-close { BACKGROUND-POSITION: -32px -208px } .ui-icon-squaresmall-plus { BACKGROUND-POSITION: -48px -208px } .ui-icon-squaresmall-minus { BACKGROUND-POSITION: -64px -208px } .ui-icon-squaresmall-close { BACKGROUND-POSITION: -80px -208px } .ui-icon-grip-dotted-vertical { BACKGROUND-POSITION: 0px -224px } .ui-icon-grip-dotted-horizontal { BACKGROUND-POSITION: -16px -224px } .ui-icon-grip-solid-vertical { BACKGROUND-POSITION: -32px -224px } .ui-icon-grip-solid-horizontal { BACKGROUND-POSITION: -48px -224px } .ui-icon-gripsmall-diagonal-se { BACKGROUND-POSITION: -64px -224px } .ui-icon-grip-diagonal-se { BACKGROUND-POSITION: -80px -224px } .ui-corner-tl { -moz-border-radius-topleft: 4px; -webkit-border-top-left-radius: 4px } .ui-corner-tr { -moz-border-radius-topright: 4px; -webkit-border-top-right-radius: 4px } .ui-corner-bl { -moz-border-radius-bottomleft: 4px; -webkit-border-bottom-left-radius: = 4px } .ui-corner-br { -moz-border-radius-bottomright: 4px; = -webkit-border-bottom-right-radius: 4px } .ui-corner-top { -moz-border-radius-topleft: 4px; -webkit-border-top-left-radius: 4px; = -moz-border-radius-topright: 4px; -webkit-border-top-right-radius: 4px } .ui-corner-bottom { -moz-border-radius-bottomleft: 4px; -webkit-border-bottom-left-radius: = 4px; -moz-border-radius-bottomright: 4px; = -webkit-border-bottom-right-radius: 4px } .ui-corner-right { -moz-border-radius-topright: 4px; -webkit-border-top-right-radius: 4px; = -moz-border-radius-bottomright: 4px; -webkit-border-bottom-right-radius: = 4px } .ui-corner-left { -moz-border-radius-topleft: 4px; -webkit-border-top-left-radius: 4px; = -moz-border-radius-bottomleft: 4px; -webkit-border-bottom-left-radius: = 4px } .ui-corner-all { -moz-border-radius: 4px; -webkit-border-radius: 4px } .ui-widget-overlay { FILTER: Alpha(Opacity=3D30); BACKGROUND: = url(../../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/smoot= hness/images/ui-bg_flat_0_aaaaaa_40x100.png) #aaaaaa repeat-x 50% 50%; = opacity: .30 } .ui-widget-shadow { FILTER: Alpha(Opacity=3D30); PADDING-BOTTOM: 8px; MARGIN: -8px 0px 0px = -8px; PADDING-LEFT: 8px; PADDING-RIGHT: 8px; BACKGROUND: = url(../../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/smoot= hness/images/ui-bg_flat_0_aaaaaa_40x100.png) #aaaaaa repeat-x 50% 50%; = PADDING-TOP: 8px; opacity: .30; -moz-border-radius: 8px; = -webkit-border-radius: 8px } .ui-accordion .ui-accordion-header { POSITION: relative; MARGIN-TOP: 1px; ZOOM: 1; CURSOR: pointer } .ui-accordion .ui-accordion-li-fix { DISPLAY: inline } .ui-accordion .ui-accordion-header-active { BORDER-BOTTOM: 0px } .ui-accordion .ui-accordion-header A { PADDING-BOTTOM: 0.5em; PADDING-LEFT: 2.2em; PADDING-RIGHT: 0.5em; = DISPLAY: block; FONT-SIZE: 1em; PADDING-TOP: 0.5em } .ui-accordion .ui-accordion-header .ui-icon { POSITION: absolute; MARGIN-TOP: -8px; TOP: 50%; LEFT: 0.5em } .ui-accordion .ui-accordion-content { POSITION: relative; PADDING-BOTTOM: 1em; MARGIN-TOP: -2px; = PADDING-LEFT: 2.2em; PADDING-RIGHT: 2.2em; DISPLAY: none; MARGIN-BOTTOM: = 2px; OVERFLOW: auto; BORDER-TOP: 0px; TOP: 1px; PADDING-TOP: 1em } .ui-accordion .ui-accordion-content-active { DISPLAY: block } .ui-datepicker { PADDING-BOTTOM: 0px; PADDING-LEFT: 0.2em; WIDTH: 17em; PADDING-RIGHT: = 0.2em; PADDING-TOP: 0.2em } .ui-datepicker .ui-datepicker-header { POSITION: relative; PADDING-BOTTOM: 0.2em; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 0.2em } .ui-datepicker .ui-datepicker-prev { POSITION: absolute; WIDTH: 1.8em; HEIGHT: 1.8em; TOP: 2px } .ui-datepicker .ui-datepicker-next { POSITION: absolute; WIDTH: 1.8em; HEIGHT: 1.8em; TOP: 2px } .ui-datepicker .ui-datepicker-prev-hover { TOP: 1px } .ui-datepicker .ui-datepicker-next-hover { TOP: 1px } .ui-datepicker .ui-datepicker-prev { LEFT: 2px } .ui-datepicker .ui-datepicker-next { RIGHT: 2px } .ui-datepicker .ui-datepicker-prev-hover { LEFT: 1px } .ui-datepicker .ui-datepicker-next-hover { RIGHT: 1px } .ui-datepicker .ui-datepicker-prev SPAN { POSITION: absolute; MARGIN-TOP: -8px; DISPLAY: block; MARGIN-LEFT: = -8px; TOP: 50%; LEFT: 50% } .ui-datepicker .ui-datepicker-next SPAN { POSITION: absolute; MARGIN-TOP: -8px; DISPLAY: block; MARGIN-LEFT: = -8px; TOP: 50%; LEFT: 50% } .ui-datepicker .ui-datepicker-title { TEXT-ALIGN: center; LINE-HEIGHT: 1.8em; MARGIN: 0px 2.3em } .ui-datepicker .ui-datepicker-title SELECT { MARGIN: 1px 0px; FLOAT: left; FONT-SIZE: 1em } .ui-datepicker SELECT.ui-datepicker-month-year { WIDTH: 100% } .ui-datepicker SELECT.ui-datepicker-month { WIDTH: 49% } .ui-datepicker SELECT.ui-datepicker-year { WIDTH: 49% } .ui-datepicker .ui-datepicker-title SELECT.ui-datepicker-year { FLOAT: right } .ui-datepicker TABLE { MARGIN: 0px 0px 0.4em; WIDTH: 100%; BORDER-COLLAPSE: collapse; = FONT-SIZE: 0.9em } .ui-datepicker TH { BORDER-BOTTOM: 0px; TEXT-ALIGN: center; BORDER-LEFT: 0px; = PADDING-BOTTOM: 0.7em; PADDING-LEFT: 0.3em; PADDING-RIGHT: 0.3em; = BORDER-TOP: 0px; FONT-WEIGHT: bold; BORDER-RIGHT: 0px; PADDING-TOP: = 0.7em } .ui-datepicker TD { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 1px; = PADDING-LEFT: 1px; PADDING-RIGHT: 1px; BORDER-TOP: 0px; BORDER-RIGHT: = 0px; PADDING-TOP: 1px } .ui-datepicker TD SPAN { TEXT-ALIGN: right; PADDING-BOTTOM: 0.2em; PADDING-LEFT: 0.2em; = PADDING-RIGHT: 0.2em; DISPLAY: block; TEXT-DECORATION: none; = PADDING-TOP: 0.2em } .ui-datepicker TD A { TEXT-ALIGN: right; PADDING-BOTTOM: 0.2em; PADDING-LEFT: 0.2em; = PADDING-RIGHT: 0.2em; DISPLAY: block; TEXT-DECORATION: none; = PADDING-TOP: 0.2em } .ui-datepicker .ui-datepicker-buttonpane { BACKGROUND-IMAGE: none; BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; = PADDING-BOTTOM: 0px; MARGIN: 0.7em 0px 0px; PADDING-LEFT: 0.2em; = PADDING-RIGHT: 0.2em; BORDER-RIGHT: 0px; PADDING-TOP: 0px } .ui-datepicker .ui-datepicker-buttonpane BUTTON { PADDING-BOTTOM: 0.3em; MARGIN: 0.5em 0.2em 0.4em; PADDING-LEFT: 0.6em; = WIDTH: auto; PADDING-RIGHT: 0.6em; FLOAT: right; OVERFLOW: visible; = CURSOR: pointer; PADDING-TOP: 0.2em } .ui-datepicker .ui-datepicker-buttonpane BUTTON.ui-datepicker-current { FLOAT: left } .ui-datepicker-multi.ui-datepicker { WIDTH: auto } .ui-datepicker-multi .ui-datepicker-group { FLOAT: left } .ui-datepicker-multi .ui-datepicker-group TABLE { MARGIN: 0px auto 0.4em; WIDTH: 95% } .ui-datepicker-multi-2 .ui-datepicker-group { WIDTH: 50% } .ui-datepicker-multi-3 .ui-datepicker-group { WIDTH: 33.3% } .ui-datepicker-multi-4 .ui-datepicker-group { WIDTH: 25% } .ui-datepicker-multi .ui-datepicker-group-last .ui-datepicker-header { BORDER-LEFT-WIDTH: 0px } .ui-datepicker-multi .ui-datepicker-group-middle .ui-datepicker-header { BORDER-LEFT-WIDTH: 0px } .ui-datepicker-multi .ui-datepicker-buttonpane { CLEAR: left } .ui-datepicker-row-break { WIDTH: 100%; CLEAR: both } .ui-datepicker-rtl { DIRECTION: rtl } .ui-datepicker-rtl .ui-datepicker-prev { RIGHT: 2px; LEFT: auto } .ui-datepicker-rtl .ui-datepicker-next { RIGHT: auto; LEFT: 2px } .ui-datepicker-rtl .ui-datepicker-prev:hover { RIGHT: 1px; LEFT: auto } .ui-datepicker-rtl .ui-datepicker-next:hover { RIGHT: auto; LEFT: 1px } .ui-datepicker-rtl .ui-datepicker-buttonpane { CLEAR: right } .ui-datepicker-rtl .ui-datepicker-buttonpane BUTTON { FLOAT: left } .ui-datepicker-rtl .ui-datepicker-buttonpane = BUTTON.ui-datepicker-current { FLOAT: right } .ui-datepicker-rtl .ui-datepicker-group { FLOAT: right } .ui-datepicker-rtl .ui-datepicker-group-last .ui-datepicker-header { BORDER-RIGHT-WIDTH: 0px; BORDER-LEFT-WIDTH: 1px } .ui-datepicker-rtl .ui-datepicker-group-middle .ui-datepicker-header { BORDER-RIGHT-WIDTH: 0px; BORDER-LEFT-WIDTH: 1px } .ui-datepicker-cover { Z-INDEX: -1; POSITION: absolute; FILTER: mask(); WIDTH: 200px; DISPLAY: = block; HEIGHT: 200px; TOP: -4px; LEFT: -4px } .ui-dialog { POSITION: relative; PADDING-BOTTOM: 0.2em; PADDING-LEFT: 0.2em; WIDTH: = 300px; PADDING-RIGHT: 0.2em; PADDING-TOP: 0.2em } .ui-dialog .ui-dialog-titlebar { POSITION: relative; PADDING-BOTTOM: 0.3em; PADDING-LEFT: 1em; = PADDING-RIGHT: 0.3em; PADDING-TOP: 0.5em } .ui-dialog .ui-dialog-title { MARGIN: 0.1em 0px 0.2em; FLOAT: left } .ui-dialog .ui-dialog-titlebar-close { POSITION: absolute; PADDING-BOTTOM: 1px; MARGIN: -10px 0px 0px; = PADDING-LEFT: 1px; WIDTH: 19px; PADDING-RIGHT: 1px; HEIGHT: 18px; TOP: = 50%; RIGHT: 0.3em; PADDING-TOP: 1px } .ui-dialog .ui-dialog-titlebar-close SPAN { MARGIN: 1px; DISPLAY: block } .ui-dialog .ui-dialog-titlebar-close:hover { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .ui-dialog .ui-dialog-titlebar-close:focus { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } .ui-dialog .ui-dialog-content { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; PADDING-BOTTOM: 0.5em; = PADDING-LEFT: 1em; PADDING-RIGHT: 1em; ZOOM: 1; BACKGROUND: none = transparent scroll repeat 0% 0%; OVERFLOW: auto; BORDER-TOP: 0px; = BORDER-RIGHT: 0px; PADDING-TOP: 0.5em } .ui-dialog .ui-dialog-buttonpane { BACKGROUND-IMAGE: none; TEXT-ALIGN: left; PADDING-BOTTOM: 0.5em; = BORDER-RIGHT-WIDTH: 0px; MARGIN: 0.5em 0px 0px; PADDING-LEFT: 0.4em; = PADDING-RIGHT: 1em; BORDER-TOP-WIDTH: 1px; BORDER-BOTTOM-WIDTH: 0px; = BORDER-LEFT-WIDTH: 0px; PADDING-TOP: 0.3em } .ui-dialog .ui-dialog-buttonpane BUTTON { PADDING-BOTTOM: 0.3em; LINE-HEIGHT: 1.4em; MARGIN: 0.5em 0.4em 0.5em = 0px; PADDING-LEFT: 0.6em; WIDTH: auto; PADDING-RIGHT: 0.6em; FLOAT: = right; OVERFLOW: visible; CURSOR: pointer; PADDING-TOP: 0.2em } .ui-dialog .ui-resizable-se { WIDTH: 14px; BOTTOM: 3px; HEIGHT: 14px; RIGHT: 3px } .ui-draggable .ui-dialog-titlebar { CURSOR: move } .ui-progressbar { TEXT-ALIGN: left; HEIGHT: 2em } .ui-progressbar .ui-progressbar-value { MARGIN: -1px; HEIGHT: 100% } .ui-resizable { POSITION: relative } .ui-resizable-handle { Z-INDEX: 99999; POSITION: absolute; DISPLAY: block; FONT-SIZE: 0.1px } .ui-resizable-disabled .ui-resizable-handle { DISPLAY: none } .ui-resizable-autohide .ui-resizable-handle { DISPLAY: none } .ui-resizable-n { WIDTH: 100%; HEIGHT: 7px; TOP: -5px; CURSOR: n-resize; LEFT: 0px } .ui-resizable-s { WIDTH: 100%; BOTTOM: -5px; HEIGHT: 7px; CURSOR: s-resize; LEFT: 0px } .ui-resizable-e { WIDTH: 7px; HEIGHT: 100%; TOP: 0px; CURSOR: e-resize; RIGHT: -5px } .ui-resizable-w { WIDTH: 7px; HEIGHT: 100%; TOP: 0px; CURSOR: w-resize; LEFT: -5px } .ui-resizable-se { WIDTH: 12px; BOTTOM: 1px; HEIGHT: 12px; CURSOR: se-resize; RIGHT: 1px } .ui-resizable-sw { WIDTH: 9px; BOTTOM: -5px; HEIGHT: 9px; CURSOR: sw-resize; LEFT: -5px } .ui-resizable-nw { WIDTH: 9px; HEIGHT: 9px; TOP: -5px; CURSOR: nw-resize; LEFT: -5px } .ui-resizable-ne { WIDTH: 9px; HEIGHT: 9px; TOP: -5px; CURSOR: ne-resize; RIGHT: -5px } .ui-slider { POSITION: relative; TEXT-ALIGN: left } .ui-slider .ui-slider-handle { Z-INDEX: 2; POSITION: absolute; WIDTH: 1.2em; HEIGHT: 1.2em; CURSOR: = default } .ui-slider .ui-slider-range { Z-INDEX: 1; BORDER-BOTTOM: 0px; POSITION: absolute; BORDER-LEFT: 0px; = DISPLAY: block; FONT-SIZE: 0.7em; BORDER-TOP: 0px; BORDER-RIGHT: 0px } .ui-slider-horizontal { HEIGHT: 0.8em } .ui-slider-horizontal .ui-slider-handle { MARGIN-LEFT: -0.6em; TOP: -0.3em } .ui-slider-horizontal .ui-slider-range { HEIGHT: 100%; TOP: 0px } .ui-slider-horizontal .ui-slider-range-min { LEFT: 0px } .ui-slider-horizontal .ui-slider-range-max { RIGHT: 0px } .ui-slider-vertical { WIDTH: 0.8em; HEIGHT: 100px } .ui-slider-vertical .ui-slider-handle { MARGIN-BOTTOM: -0.6em; MARGIN-LEFT: 0px; LEFT: -0.3em } .ui-slider-vertical .ui-slider-range { WIDTH: 100%; LEFT: 0px } .ui-slider-vertical .ui-slider-range-min { BOTTOM: 0px } .ui-slider-vertical .ui-slider-range-max { TOP: 0px } .ui-tabs { PADDING-BOTTOM: 0.2em; PADDING-LEFT: 0.2em; PADDING-RIGHT: 0.2em; ZOOM: = 1; PADDING-TOP: 0.2em } .ui-tabs .ui-tabs-nav { POSITION: relative; PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; = PADDING-LEFT: 0.2em; PADDING-RIGHT: 0.2em; LIST-STYLE-IMAGE: none; = PADDING-TOP: 0.2em } .ui-tabs .ui-tabs-nav LI { POSITION: relative; PADDING-BOTTOM: 0px; MARGIN: 0px 0.2em -1px 0px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: left; BORDER-BOTTOM-WIDTH: = 0px !important; PADDING-TOP: 0px } .ui-tabs .ui-tabs-nav LI A { PADDING-BOTTOM: 0.5em; PADDING-LEFT: 1em; PADDING-RIGHT: 1em; FLOAT: = left; TEXT-DECORATION: none; PADDING-TOP: 0.5em } .ui-tabs .ui-tabs-nav LI.ui-tabs-selected { PADDING-BOTTOM: 1px; BORDER-BOTTOM-WIDTH: 0px } .ui-tabs .ui-tabs-nav LI.ui-tabs-selected A { CURSOR: text } .ui-tabs .ui-tabs-nav LI.ui-state-disabled A { CURSOR: text } .ui-tabs .ui-tabs-nav LI.ui-state-processing A { CURSOR: text } .ui-tabs .ui-tabs-nav LI A { CURSOR: pointer } .ui-tabs-collapsible.ui-tabs .ui-tabs-nav LI.ui-tabs-selected A { CURSOR: pointer } .ui-tabs .ui-tabs-panel { PADDING-BOTTOM: 1em; BORDER-RIGHT-WIDTH: 0px; PADDING-LEFT: 1.4em; = PADDING-RIGHT: 1.4em; DISPLAY: block; BACKGROUND: none transparent = scroll repeat 0% 0%; BORDER-TOP-WIDTH: 0px; BORDER-BOTTOM-WIDTH: 0px; = BORDER-LEFT-WIDTH: 0px; PADDING-TOP: 1em } .ui-tabs .ui-tabs-hide { DISPLAY: none !important } ------=_NextPart_000_0000_01CB4AA7.A6ECED10 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nejm.org/cssJawr/N537617391/templates/jsp/_style2/_mms/_nejm/css/jquery.jcarousel.css .jcarousel-container { POSITION: relative } .jcarousel-clip { Z-INDEX: 2; POSITION: relative; PADDING-BOTTOM: 0px; MARGIN: 0px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; OVERFLOW: hidden; PADDING-TOP: = 0px } .jcarousel-list { Z-INDEX: 1; POSITION: relative; PADDING-BOTTOM: 0px; MARGIN: 0px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; OVERFLOW: hidden; TOP: 0px; = PADDING-TOP: 0px; LEFT: 0px } .jcarousel-list LI { LIST-STYLE-TYPE: none; WIDTH: 75px; FLOAT: left; HEIGHT: 75px; = LIST-STYLE-IMAGE: none } .jcarousel-item { LIST-STYLE-TYPE: none; WIDTH: 75px; FLOAT: left; HEIGHT: 75px; = LIST-STYLE-IMAGE: none } .jcarousel-next { Z-INDEX: 3; DISPLAY: none } .jcarousel-prev { Z-INDEX: 3; DISPLAY: none } ------=_NextPart_000_0000_01CB4AA7.A6ECED10 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nejm.org/cssJawr/N604307549/templates/jsp/_style2/_mms/_nejm/css/jquery.cluetip.css #cluetip-close IMG { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; BORDER-TOP: 0px; BORDER-RIGHT: = 0px } #cluetip-title { OVERFLOW: hidden } #cluetip-title #cluetip-close { POSITION: relative; FLOAT: right } #cluetip-waitimage { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/w= ait.gif); POSITION: absolute; WIDTH: 43px; HEIGHT: 11px } .cluetip-arrows { POSITION: absolute; WIDTH: 11px; DISPLAY: none; BACKGROUND-REPEAT: = no-repeat; BACKGROUND-POSITION: 0px 0px; HEIGHT: 22px; TOP: 0px; LEFT: = -11px } #cluetip-extra { DISPLAY: none } .cluetip-default { BACKGROUND-COLOR: #d9d9c2 } .cluetip-default #cluetip-outer { POSITION: relative; BACKGROUND-COLOR: #d9d9c2; MARGIN: 0px } .cluetip-default H3#cluetip-title { PADDING-BOTTOM: 4px; BACKGROUND-COLOR: #87876a; MARGIN: 0px 0px 5px; = PADDING-LEFT: 10px; PADDING-RIGHT: 10px; COLOR: #fff; FONT-SIZE: 1.1em; = FONT-WEIGHT: normal; PADDING-TOP: 8px } .cluetip-default #cluetip-title A { COLOR: #d9d9c2; FONT-SIZE: 0.95em } .cluetip-default #cluetip-inner { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; PADDING-RIGHT: 10px; = PADDING-TOP: 10px } .cluetip-default DIV#cluetip-close { TEXT-ALIGN: right; MARGIN: 0px 5px 5px; COLOR: #900 } .clue-right-default .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/d= arrowleft.gif) } .clue-left-default .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/d= arrowright.gif); MARGIN-RIGHT: -11px; LEFT: 100% } .clue-top-default .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/d= arrowdown.gif); WIDTH: 22px; HEIGHT: 11px; MARGIN-LEFT: -11px; TOP: = 100%; LEFT: 50% } .clue-bottom-default .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/d= arrowup.gif); WIDTH: 22px; HEIGHT: 11px; MARGIN-LEFT: -11px; TOP: -11px; = LEFT: 50% } .cluetip-jtip { BACKGROUND-COLOR: transparent } .cluetip-jtip #cluetip-outer { BORDER-BOTTOM: #ccc 2px solid; POSITION: relative; BORDER-LEFT: #ccc = 2px solid; BACKGROUND-COLOR: #fff; BORDER-TOP: #ccc 2px solid; = BORDER-RIGHT: #ccc 2px solid } .cluetip-jtip H3#cluetip-title { PADDING-BOTTOM: 2px; BACKGROUND-COLOR: #ccc; MARGIN: 0px 0px 5px; = PADDING-LEFT: 5px; PADDING-RIGHT: 5px; COLOR: #333; FONT-SIZE: 16px; = FONT-WEIGHT: normal; PADDING-TOP: 2px } .cluetip-jtip #cluetip-inner { PADDING-BOTTOM: 5px; PADDING-LEFT: 5px; PADDING-RIGHT: 5px; DISPLAY: = inline-block; PADDING-TOP: 0px } .cluetip-jtip DIV#cluetip-close { TEXT-ALIGN: right; MARGIN: 0px 5px 5px; COLOR: #900 } .clue-right-jtip .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/a= rrowleft.gif) } .clue-left-jtip .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/a= rrowright.gif); MARGIN-RIGHT: -11px; LEFT: 100% } .clue-top-jtip .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/a= rrowdown.gif); WIDTH: 22px; HEIGHT: 11px; MARGIN-LEFT: -11px; TOP: 100%; = LEFT: 50% } .clue-bottom-jtip .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/a= rrowup.gif); WIDTH: 22px; HEIGHT: 11px; MARGIN-LEFT: -11px; TOP: -11px; = LEFT: 50% } .cluetip-rounded { MARGIN-TOP: 10px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/b= l.gif) no-repeat 0px 100%; MARGIN-LEFT: 12px } .cluetip-rounded #cluetip-outer { MARGIN-TOP: -12px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/t= l.gif) no-repeat 0px 0px } .cluetip-rounded #cluetip-title { POSITION: relative; PADDING-BOTTOM: 0px; BACKGROUND-COLOR: transparent; = MARGIN: 0px -12px 0px 0px; PADDING-LEFT: 12px; PADDING-RIGHT: 12px; = PADDING-TOP: 12px } .cluetip-rounded #cluetip-extra { POSITION: absolute; MARGIN: -12px -12px 0px 0px; WIDTH: 12px; DISPLAY: = block; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/t= r.gif) no-repeat 100% 0px; HEIGHT: 30px; TOP: 0px; RIGHT: 0px } .cluetip-rounded #cluetip-inner { POSITION: relative; PADDING-BOTTOM: 12px; MARGIN: -18px -12px 0px 0px; = PADDING-LEFT: 12px; PADDING-RIGHT: 12px; BACKGROUND: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/b= r.gif) no-repeat 100% 100%; PADDING-TOP: 5px } .cluetip-rounded DIV#cluetip-close { TEXT-ALIGN: right; MARGIN: 0px 5px 5px; BACKGROUND: none transparent = scroll repeat 0% 0%; COLOR: #009 } .cluetip-rounded DIV#cluetip-close A { COLOR: #777 } .clue-right-rounded .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/r= arrowleft.gif) } .clue-left-rounded .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/r= arrowright.gif); MARGIN-LEFT: 12px; LEFT: 100% } .clue-top-rounded .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/r= arrowdown.gif); WIDTH: 22px; HEIGHT: 11px; MARGIN-LEFT: -11px; TOP: = 100%; LEFT: 50% } .clue-bottom-rounded .cluetip-arrows { BACKGROUND-IMAGE: = url(../../../../../../../../templates/jsp/_style2/_mms/_nejm/css/images/r= arrowup.gif); WIDTH: 22px; HEIGHT: 11px; MARGIN-LEFT: -11px; TOP: -23px; = LEFT: 50% } .cluetip-rounded #cluetip-title { ZOOM: 1 } .cluetip-rounded #cluetip-inner { ZOOM: 1 } ------=_NextPart_000_0000_01CB4AA7.A6ECED10 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://assets.resultspage.com/autosuggest/autosuggest.css .autocomplete { BORDER-BOTTOM: black 1px solid; POSITION: absolute; TEXT-ALIGN: left = !important; BORDER-LEFT: black 1px solid; OVERFLOW-X: hidden; = BACKGROUND-COLOR: white; FONT-FAMILY: Tahoma; VISIBILITY: hidden; = FONT-SIZE: 8pt; OVERFLOW: auto; BORDER-TOP: black 1px solid; CURSOR: = default; BORDER-RIGHT: black 1px solid } .autocomplete_item { PADDING-BOTTOM: 1px; PADDING-LEFT: 5px; PADDING-RIGHT: 1px; COLOR: = black; PADDING-TOP: 1px } .autocomplete_item_highlighted { PADDING-BOTTOM: 1px; PADDING-LEFT: 5px; PADDING-RIGHT: 1px; COLOR: = black; PADDING-TOP: 1px } .autocomplete_item_highlighted { BACKGROUND-COLOR: #feffaf } DIV.autocomplete_footer { PADDING-BOTTOM: 1px; MARGIN-TOP: 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this[ num ];=0A= },=0A= =0A= // Take an array of elements and push it onto the stack=0A= // (returning the new matched element set)=0A= pushStack: function( elems, name, selector ) {=0A= // Build a new jQuery matched element set=0A= var ret =3D jQuery( elems );=0A= =0A= // Add the old object onto the stack (as a reference)=0A= ret.prevObject =3D this;=0A= =0A= ret.context =3D this.context;=0A= =0A= if ( name =3D=3D=3D "find" )=0A= ret.selector =3D this.selector + (this.selector ? 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Calling detachEvent on the=0A= // clone will also remove the events from the orignal=0A= // In order to get around this, we use innerHTML.=0A= // Unfortunately, this means some modifications to=0A= // attributes in IE that are actually only stored=0A= // as properties will not be copied (such as the=0A= // the name attribute on an input).=0A= var html =3D this.outerHTML;=0A= if ( !html ) {=0A= var div =3D this.ownerDocument.createElement("div");=0A= div.appendChild( this.cloneNode(true) );=0A= html =3D div.innerHTML;=0A= }=0A= =0A= return jQuery.clean([html.replace(/ jQuery\d+=3D"(?:\d+|null)"/g, = "").replace(/^\s*/, "")])[0];=0A= } else=0A= return this.cloneNode(true);=0A= });=0A= =0A= // Copy the events from the original to the clone=0A= if ( events =3D=3D=3D true ) {=0A= var orig =3D this.find("*").andSelf(), i =3D 0;=0A= =0A= ret.find("*").andSelf().each(function(){=0A= if ( this.nodeName !=3D=3D orig[i].nodeName )=0A= return;=0A= =0A= var events =3D jQuery.data( orig[i], "events" );=0A= =0A= for ( var type in events ) {=0A= for ( var handler in events[ type ] ) {=0A= jQuery.event.add( this, type, events[ type ][ handler ], events[ = type ][ handler ].data );=0A= }=0A= }=0A= =0A= i++;=0A= });=0A= }=0A= =0A= // Return the cloned set=0A= return ret;=0A= },=0A= =0A= filter: function( selector ) {=0A= return this.pushStack(=0A= jQuery.isFunction( selector ) &&=0A= jQuery.grep(this, function(elem, i){=0A= return selector.call( elem, i );=0A= }) ||=0A= =0A= jQuery.multiFilter( selector, jQuery.grep(this, function(elem){=0A= return elem.nodeType =3D=3D=3D 1;=0A= }) ), "filter", selector );=0A= },=0A= =0A= closest: function( selector ) {=0A= var pos =3D jQuery.expr.match.POS.test( selector ) ? jQuery(selector) = : null,=0A= closer =3D 0;=0A= =0A= return this.map(function(){=0A= var cur =3D this;=0A= while ( cur && cur.ownerDocument ) {=0A= if ( pos ? pos.index(cur) > -1 : jQuery(cur).is(selector) ) {=0A= jQuery.data(cur, "closest", closer);=0A= return cur;=0A= }=0A= cur =3D cur.parentNode;=0A= closer++;=0A= }=0A= });=0A= },=0A= =0A= not: function( selector ) {=0A= if ( typeof selector =3D=3D=3D "string" )=0A= // test special case where just one selector is passed in=0A= if ( isSimple.test( selector ) )=0A= return this.pushStack( jQuery.multiFilter( selector, this, true ), = "not", selector );=0A= else=0A= selector =3D jQuery.multiFilter( selector, this );=0A= =0A= var isArrayLike =3D selector.length && selector[selector.length - 1] = !=3D=3D undefined && !selector.nodeType;=0A= return this.filter(function() {=0A= return isArrayLike ? jQuery.inArray( this, selector ) < 0 : this !=3D = selector;=0A= });=0A= },=0A= =0A= add: function( selector ) {=0A= return this.pushStack( jQuery.unique( jQuery.merge(=0A= this.get(),=0A= typeof selector =3D=3D=3D "string" ?=0A= jQuery( selector ) :=0A= jQuery.makeArray( selector )=0A= )));=0A= },=0A= =0A= is: function( selector ) {=0A= return !!selector && jQuery.multiFilter( selector, this ).length > 0;=0A= },=0A= =0A= hasClass: function( selector ) {=0A= return !!selector && this.is( "." + selector );=0A= },=0A= =0A= val: function( value ) {=0A= if ( value =3D=3D=3D undefined ) { =0A= var elem =3D this[0];=0A= =0A= if ( elem ) {=0A= if( jQuery.nodeName( elem, 'option' ) )=0A= return (elem.attributes.value || {}).specified ? elem.value : = elem.text;=0A= =0A= // We need to handle select boxes special=0A= if ( jQuery.nodeName( elem, "select" ) ) {=0A= var index =3D elem.selectedIndex,=0A= values =3D [],=0A= options =3D elem.options,=0A= one =3D elem.type =3D=3D "select-one";=0A= =0A= // Nothing was selected=0A= if ( index < 0 )=0A= return null;=0A= =0A= // Loop through all the selected options=0A= for ( var i =3D one ? index : 0, max =3D one ? index + 1 : = options.length; i < max; i++ ) {=0A= var option =3D options[ i ];=0A= =0A= if ( option.selected ) {=0A= // Get the specifc value for the option=0A= value =3D jQuery(option).val();=0A= =0A= // We don't need an array for one selects=0A= if ( one )=0A= return value;=0A= =0A= // Multi-Selects return an array=0A= values.push( value );=0A= }=0A= }=0A= =0A= return values; =0A= }=0A= =0A= // Everything else, we just grab the value=0A= return (elem.value || "").replace(/\r/g, "");=0A= =0A= }=0A= =0A= return undefined;=0A= }=0A= =0A= if ( typeof value =3D=3D=3D "number" )=0A= value +=3D '';=0A= =0A= return this.each(function(){=0A= if ( this.nodeType !=3D 1 )=0A= return;=0A= =0A= if ( jQuery.isArray(value) && /radio|checkbox/.test( this.type ) )=0A= this.checked =3D (jQuery.inArray(this.value, value) >=3D 0 ||=0A= jQuery.inArray(this.name, value) >=3D 0);=0A= =0A= else if ( jQuery.nodeName( this, "select" ) ) {=0A= var values =3D jQuery.makeArray(value);=0A= =0A= jQuery( "option", this ).each(function(){=0A= this.selected =3D (jQuery.inArray( this.value, values ) >=3D 0 ||=0A= jQuery.inArray( this.text, values ) >=3D 0);=0A= });=0A= =0A= if ( !values.length )=0A= this.selectedIndex =3D -1;=0A= =0A= } else=0A= this.value =3D value;=0A= });=0A= },=0A= =0A= html: function( value ) {=0A= return value =3D=3D=3D undefined ?=0A= (this[0] ?=0A= this[0].innerHTML.replace(/ jQuery\d+=3D"(?:\d+|null)"/g, "") :=0A= null) :=0A= this.empty().append( value );=0A= },=0A= =0A= replaceWith: function( value ) {=0A= return this.after( value ).remove();=0A= },=0A= =0A= eq: function( i ) {=0A= return this.slice( i, +i + 1 );=0A= },=0A= =0A= slice: function() {=0A= return this.pushStack( Array.prototype.slice.apply( this, arguments ),=0A= "slice", Array.prototype.slice.call(arguments).join(",") );=0A= },=0A= =0A= map: function( callback ) {=0A= return this.pushStack( jQuery.map(this, function(elem, i){=0A= return callback.call( elem, i, elem );=0A= }));=0A= },=0A= =0A= andSelf: function() {=0A= return this.add( this.prevObject );=0A= },=0A= =0A= domManip: function( args, table, callback ) {=0A= if ( this[0] ) {=0A= var fragment =3D (this[0].ownerDocument || = this[0]).createDocumentFragment(),=0A= scripts =3D jQuery.clean( args, (this[0].ownerDocument || this[0]), = fragment ),=0A= first =3D fragment.firstChild;=0A= =0A= if ( first )=0A= for ( var i =3D 0, l =3D this.length; i < l; i++ )=0A= callback.call( root(this[i], first), this.length > 1 || i > 0 ?=0A= fragment.cloneNode(true) : fragment );=0A= =0A= if ( scripts )=0A= jQuery.each( scripts, evalScript );=0A= }=0A= =0A= return this;=0A= =0A= function root( elem, cur ) {=0A= return table && jQuery.nodeName(elem, "table") && = jQuery.nodeName(cur, "tr") ?=0A= (elem.getElementsByTagName("tbody")[0] ||=0A= elem.appendChild(elem.ownerDocument.createElement("tbody"))) :=0A= elem;=0A= }=0A= }=0A= };=0A= =0A= // Give the init function the jQuery prototype for later instantiation=0A= jQuery.fn.init.prototype =3D jQuery.fn;=0A= =0A= function evalScript( i, elem ) {=0A= if ( elem.src )=0A= jQuery.ajax({=0A= url: elem.src,=0A= async: false,=0A= dataType: "script"=0A= });=0A= =0A= else=0A= jQuery.globalEval( elem.text || elem.textContent || elem.innerHTML || = "" );=0A= =0A= if ( elem.parentNode )=0A= elem.parentNode.removeChild( elem );=0A= }=0A= =0A= function now(){=0A= return +new Date;=0A= }=0A= =0A= jQuery.extend =3D jQuery.fn.extend =3D function() {=0A= // copy reference to target object=0A= var target =3D arguments[0] || {}, i =3D 1, length =3D = arguments.length, deep =3D false, options;=0A= =0A= // Handle a deep copy situation=0A= if ( typeof target =3D=3D=3D "boolean" ) {=0A= deep =3D target;=0A= target =3D arguments[1] || {};=0A= // skip the boolean and the target=0A= i =3D 2;=0A= }=0A= =0A= // Handle case when target is a string or something (possible in deep = copy)=0A= if ( typeof target !=3D=3D "object" && !jQuery.isFunction(target) )=0A= target =3D {};=0A= =0A= // extend jQuery itself if only one argument is passed=0A= if ( length =3D=3D i ) {=0A= target =3D this;=0A= --i;=0A= }=0A= =0A= for ( ; i < length; i++ )=0A= // Only deal with non-null/undefined values=0A= if ( (options =3D arguments[ i ]) !=3D null )=0A= // Extend the base object=0A= for ( var name in options ) {=0A= var src =3D target[ name ], copy =3D options[ name ];=0A= =0A= // Prevent never-ending loop=0A= if ( target =3D=3D=3D copy )=0A= continue;=0A= =0A= // Recurse if we're merging object values=0A= if ( deep && copy && typeof copy =3D=3D=3D "object" && = !copy.nodeType )=0A= target[ name ] =3D jQuery.extend( deep, =0A= // Never move original objects, clone them=0A= src || ( copy.length !=3D null ? [ ] : { } )=0A= , copy );=0A= =0A= // Don't bring in undefined values=0A= else if ( copy !=3D=3D undefined )=0A= target[ name ] =3D copy;=0A= =0A= }=0A= =0A= // Return the modified object=0A= return target;=0A= };=0A= =0A= // exclude the following css properties to add px=0A= var exclude =3D /z-?index|font-?weight|opacity|zoom|line-?height/i,=0A= // cache defaultView=0A= defaultView =3D document.defaultView || {},=0A= toString =3D Object.prototype.toString;=0A= =0A= jQuery.extend({=0A= noConflict: function( deep ) {=0A= window.$ =3D _$;=0A= =0A= if ( deep )=0A= window.jQuery =3D _jQuery;=0A= =0A= return jQuery;=0A= },=0A= =0A= // See test/unit/core.js for details concerning isFunction.=0A= // Since version 1.3, DOM methods and functions like alert=0A= // aren't supported. They return false on IE (#2968).=0A= isFunction: function( obj ) {=0A= return toString.call(obj) =3D=3D=3D "[object Function]";=0A= },=0A= =0A= isArray: function( obj ) {=0A= return toString.call(obj) =3D=3D=3D "[object Array]";=0A= },=0A= =0A= // check if an element is in a (or is an) XML document=0A= isXMLDoc: function( elem ) {=0A= return elem.nodeType =3D=3D=3D 9 && elem.documentElement.nodeName = !=3D=3D "HTML" ||=0A= !!elem.ownerDocument && jQuery.isXMLDoc( elem.ownerDocument );=0A= },=0A= =0A= // Evalulates a script in a global context=0A= globalEval: function( data ) {=0A= if ( data && /\S/.test(data) ) {=0A= // Inspired by code by Andrea Giammarchi=0A= // = http://webreflection.blogspot.com/2007/08/global-scope-evaluation-and-dom= .html=0A= var head =3D document.getElementsByTagName("head")[0] || = document.documentElement,=0A= script =3D document.createElement("script");=0A= =0A= script.type =3D "text/javascript";=0A= if ( jQuery.support.scriptEval )=0A= script.appendChild( document.createTextNode( data ) );=0A= else=0A= script.text =3D data;=0A= =0A= // Use insertBefore instead of appendChild to circumvent an IE6 bug.=0A= // This arises when a base node is used (#2709).=0A= head.insertBefore( script, head.firstChild );=0A= head.removeChild( script );=0A= }=0A= },=0A= =0A= nodeName: function( elem, name ) {=0A= return elem.nodeName && elem.nodeName.toUpperCase() =3D=3D = name.toUpperCase();=0A= },=0A= =0A= // args is for internal usage only=0A= each: function( object, callback, args ) {=0A= var name, i =3D 0, length =3D object.length;=0A= =0A= if ( args ) {=0A= if ( length =3D=3D=3D undefined ) {=0A= for ( name in object )=0A= if ( callback.apply( object[ name ], args ) =3D=3D=3D false )=0A= break;=0A= } else=0A= for ( ; i < length; )=0A= if ( callback.apply( object[ i++ ], args ) =3D=3D=3D false )=0A= break;=0A= =0A= // A special, fast, case for the most common use of each=0A= } else {=0A= if ( length =3D=3D=3D undefined ) {=0A= for ( name in object )=0A= if ( callback.call( object[ name ], name, object[ name ] ) = =3D=3D=3D false )=0A= break;=0A= } else=0A= for ( var value =3D object[0];=0A= i < length && callback.call( value, i, value ) !=3D=3D false; value = =3D object[++i] ){}=0A= }=0A= =0A= return object;=0A= },=0A= =0A= prop: function( elem, value, type, i, name ) {=0A= // Handle executable functions=0A= if ( jQuery.isFunction( value ) )=0A= value =3D value.call( elem, i );=0A= =0A= // Handle passing in a number to a CSS property=0A= return typeof value =3D=3D=3D "number" && type =3D=3D "curCSS" && = !exclude.test( name ) ?=0A= value + "px" :=0A= value;=0A= },=0A= =0A= className: {=0A= // internal only, use addClass("class")=0A= add: function( elem, classNames ) {=0A= jQuery.each((classNames || "").split(/\s+/), function(i, className){=0A= if ( elem.nodeType =3D=3D 1 && !jQuery.className.has( = elem.className, className ) )=0A= elem.className +=3D (elem.className ? " " : "") + className;=0A= });=0A= },=0A= =0A= // internal only, use removeClass("class")=0A= remove: function( elem, classNames ) {=0A= if (elem.nodeType =3D=3D 1)=0A= elem.className =3D classNames !=3D=3D undefined ?=0A= jQuery.grep(elem.className.split(/\s+/), function(className){=0A= return !jQuery.className.has( classNames, className );=0A= }).join(" ") :=0A= "";=0A= },=0A= =0A= // internal only, use hasClass("class")=0A= has: function( elem, className ) {=0A= return elem && jQuery.inArray( className, (elem.className || = elem).toString().split(/\s+/) ) > -1;=0A= }=0A= },=0A= =0A= // A method for quickly swapping in/out CSS properties to get correct = calculations=0A= swap: function( elem, options, callback ) {=0A= var old =3D {};=0A= // Remember the old values, and insert the new ones=0A= for ( var name in options ) {=0A= old[ name ] =3D elem.style[ name ];=0A= elem.style[ name ] =3D options[ name ];=0A= }=0A= =0A= callback.call( elem );=0A= =0A= // Revert the old values=0A= for ( var name in options )=0A= elem.style[ name ] =3D old[ name ];=0A= },=0A= =0A= css: function( elem, name, force, extra ) {=0A= if ( name =3D=3D "width" || name =3D=3D "height" ) {=0A= var val, props =3D { position: "absolute", visibility: "hidden", = display:"block" }, which =3D name =3D=3D "width" ? [ "Left", "Right" ] : = [ "Top", "Bottom" ];=0A= =0A= function getWH() {=0A= val =3D name =3D=3D "width" ? elem.offsetWidth : elem.offsetHeight;=0A= =0A= if ( extra =3D=3D=3D "border" )=0A= return;=0A= =0A= jQuery.each( which, function() {=0A= if ( !extra )=0A= val -=3D parseFloat(jQuery.curCSS( elem, "padding" + this, true)) = || 0;=0A= if ( extra =3D=3D=3D "margin" )=0A= val +=3D parseFloat(jQuery.curCSS( elem, "margin" + this, true)) = || 0;=0A= else=0A= val -=3D parseFloat(jQuery.curCSS( elem, "border" + this + = "Width", true)) || 0;=0A= });=0A= }=0A= =0A= if ( elem.offsetWidth !=3D=3D 0 )=0A= getWH();=0A= else=0A= jQuery.swap( elem, props, getWH );=0A= =0A= return Math.max(0, Math.round(val));=0A= }=0A= =0A= return jQuery.curCSS( elem, name, force );=0A= },=0A= =0A= curCSS: function( elem, name, force ) {=0A= var ret, style =3D elem.style;=0A= =0A= // We need to handle opacity special in IE=0A= if ( name =3D=3D "opacity" && !jQuery.support.opacity ) {=0A= ret =3D jQuery.attr( style, "opacity" );=0A= =0A= return ret =3D=3D "" ?=0A= "1" :=0A= ret;=0A= }=0A= =0A= // Make sure we're using the right name for getting the float value=0A= if ( name.match( /float/i ) )=0A= name =3D styleFloat;=0A= =0A= if ( !force && style && style[ name ] )=0A= ret =3D style[ name ];=0A= =0A= else if ( defaultView.getComputedStyle ) {=0A= =0A= // Only "float" is needed here=0A= if ( name.match( /float/i ) )=0A= name =3D "float";=0A= =0A= name =3D name.replace( /([A-Z])/g, "-$1" ).toLowerCase();=0A= =0A= var computedStyle =3D defaultView.getComputedStyle( elem, null );=0A= =0A= if ( computedStyle )=0A= ret =3D computedStyle.getPropertyValue( name );=0A= =0A= // We should always get a number back from opacity=0A= if ( name =3D=3D "opacity" && ret =3D=3D "" )=0A= ret =3D "1";=0A= =0A= } else if ( elem.currentStyle ) {=0A= var camelCase =3D name.replace(/\-(\w)/g, function(all, letter){=0A= return letter.toUpperCase();=0A= });=0A= =0A= ret =3D elem.currentStyle[ name ] || elem.currentStyle[ camelCase ];=0A= =0A= // From the awesome hack by Dean Edwards=0A= // http://erik.eae.net/archives/2007/07/27/18.54.15/#comment-102291=0A= =0A= // If we're not dealing with a regular pixel number=0A= // but a number that has a weird ending, we need to convert it to = pixels=0A= if ( !/^\d+(px)?$/i.test( ret ) && /^\d/.test( ret ) ) {=0A= // Remember the original values=0A= var left =3D style.left, rsLeft =3D elem.runtimeStyle.left;=0A= =0A= // Put in the new values to get a computed value out=0A= elem.runtimeStyle.left =3D elem.currentStyle.left;=0A= style.left =3D ret || 0;=0A= ret =3D style.pixelLeft + "px";=0A= =0A= // Revert the changed values=0A= style.left =3D left;=0A= elem.runtimeStyle.left =3D rsLeft;=0A= }=0A= }=0A= =0A= return ret;=0A= },=0A= =0A= clean: function( elems, context, fragment ) {=0A= context =3D context || document;=0A= =0A= // !context.createElement fails in IE with an error but returns typeof = 'object'=0A= if ( typeof context.createElement =3D=3D=3D "undefined" )=0A= context =3D context.ownerDocument || context[0] && = context[0].ownerDocument || document;=0A= =0A= // If a single string is passed in and it's a single tag=0A= // just do a createElement and skip the rest=0A= if ( !fragment && elems.length =3D=3D=3D 1 && typeof elems[0] = =3D=3D=3D "string" ) {=0A= var match =3D /^<(\w+)\s*\/?>$/.exec(elems[0]);=0A= if ( match )=0A= return [ context.createElement( match[1] ) ];=0A= }=0A= =0A= var ret =3D [], scripts =3D [], div =3D context.createElement("div");=0A= =0A= jQuery.each(elems, function(i, elem){=0A= if ( typeof elem =3D=3D=3D "number" )=0A= elem +=3D '';=0A= =0A= if ( !elem )=0A= return;=0A= =0A= // Convert html string into DOM nodes=0A= if ( typeof elem =3D=3D=3D "string" ) {=0A= // Fix "XHTML"-style tags in all browsers=0A= elem =3D elem.replace(/(<(\w+)[^>]*?)\/>/g, function(all, front, = tag){=0A= return = tag.match(/^(abbr|br|col|img|input|link|meta|param|hr|area|embed)$/i) ?=0A= all :=0A= front + ">";=0A= });=0A= =0A= // Trim whitespace, otherwise indexOf won't work as expected=0A= var tags =3D elem.replace(/^\s+/, "").substring(0, 10).toLowerCase();=0A= =0A= var wrap =3D=0A= // option or optgroup=0A= !tags.indexOf("", "" ] ||=0A= =0A= !tags.indexOf("", "" ] ||=0A= =0A= tags.match(/^<(thead|tbody|tfoot|colg|cap)/) &&=0A= [ 1, "", "
" ] ||=0A= =0A= !tags.indexOf("", "" ] ||=0A= =0A= // matched above=0A= (!tags.indexOf("", "" ] ||=0A= =0A= !tags.indexOf("", "" ] ||=0A= =0A= // IE can't serialize and