From: Subject: Rethinking the antibody-dependent enhancement dengue hemorrhagic fever model Date: Wed, 9 Dec 2009 20:34:45 -0800 MIME-Version: 1.0 Content-Type: multipart/related; type="text/html"; boundary="----=_NextPart_000_0033_01CA790F.0B5A0640" X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.5579 This is a multi-part message in MIME format. ------=_NextPart_000_0033_01CA790F.0B5A0640 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.sciencedaily.com/releases/2009/10/091026220005.htm Rethinking the = antibody-dependent enhancement dengue hemorrhagic fever model
3D"ScienceDaily:

Rethinking the Antibody-Dependent = Enhancement Dengue=20 Hemorrhagic Fever Model

ScienceDaily (Nov. 20, 2009) =97 = Research=20 recently published in PLoS Medicine challenges the dogma of the = antibody-dependent enhancement model (ADE) for the development of dengue = hemorrhagic fever (DHF).

Dengue virus infection usually causes a severe 'flu like illness, = although=20 symptoms may be mild in young children. DHF, however, is a severe and = sometimes=20 fatal complication of dengue virus infection that affects about half a = million=20 people every year. DHF patients usually fall into two groups; children = and=20 adults who become infected with a second dengue virus serotype after an = initial=20 ''primary'' dengue virus infection with a different serotype, and = infants with=20 primary dengue virus infections born to mothers who have some dengue = virus=20 immunity. The current model for development of DHF in infants around 6 = months=20 old is that anti-dengue virus antibodies transferred from a = dengue-immune mother=20 to her child somehow enhance dengue virus infection, resulting in more = severe=20 symptoms (the 'antibody-dependent enhancement' model).

A prospective nested case-control study of infant dengue carried out = by=20 Daniel Libraty (of the University of Massachusetts Medical School, = Worcester,=20 MA) and colleagues reveals that maternal antibodies against dengue = protect=20 infants from the full spectrum of dengue disease. They also found that = all=20 infants with symptomatic dengue virus infection had antibodies with = measurable=20 ADE activity, but that there was no link between the amount of ADE = activity and=20 the development of DHF. They failed to find evidence supporting a role = for the=20 ADE model of development of DHF but did find that a higher = weight-for-age was a=20 risk factor for DHF.

The authors conclude that 'the results should encourage a rethinking = or=20 refinement of the currently promulgated ADE model for infant DHF, = promote=20 prospective studies of infant dengue and stimulate new directions of = research=20 into novel potential mechanisms for infant DHF'.

This study was supported by National Institutes of Health grant U01=20 AI065654.

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Adapted from materials provided by Public = Library of=20 Science, via EurekAlert!, a service of AAAS.

Journal Reference:

  • Libraty et al. A Prospective Nested Case-Control Study of = Dengue=20 in Infants: Rethinking and Refining the Antibody-Dependent Enhancement = Dengue=20 Hemorrhagic Fever Model. PLoS Medicine, 2009; 6 = (10):=20 e1000171 DOI: 10.1371/journal.pmed.1000171
    • =20
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    Note: If no author is given, the source is cited=20 instead.

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PADDING-LEFT: 0px; WIDTH: 77em; = PADDING-RIGHT: 0px; PADDING-TOP: 0px } #sectiontabs { PADDING-BOTTOM: 0px; LINE-HEIGHT: 15px; LIST-STYLE-TYPE: none; MARGIN: = 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: left; FONT-SIZE: = 13px; LIST-STYLE-IMAGE: none; PADDING-TOP: 0px } #sectiontabs UL { PADDING-BOTTOM: 0px; LINE-HEIGHT: 15px; LIST-STYLE-TYPE: none; MARGIN: = 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: left; FONT-SIZE: = 13px; LIST-STYLE-IMAGE: none; PADDING-TOP: 0px } #sectiontabs A { PADDING-BOTTOM: 2px; PADDING-LEFT: 0px; WIDTH: 9em; PADDING-RIGHT: 0px; = DISPLAY: block; HEIGHT: 15px; TEXT-DECORATION: none; PADDING-TOP: 2px } #sectiontabs LI { PADDING-BOTTOM: 0px; MARGIN: 5px 4px 0px; PADDING-LEFT: 0px; WIDTH: = 9em; PADDING-RIGHT: 0px; DISPLAY: inline; FLOAT: left; PADDING-TOP: 0px } #sectiontabs LI A { TEXT-ALIGN: center; BACKGROUND-COLOR: #eee; MARGIN: 0px; COLOR: #009 } #sectiontabs LI A.thissection { BACKGROUND-COLOR: #fff; COLOR: #900 } #sectiontabs LI A:hover { BACKGROUND-COLOR: #fff; COLOR: #900 } #sectiontabs LI UL { POSITION: absolute; MARGIN: 0px; WIDTH: 155px; LEFT: -999em } #sectiontabs LI UL LI { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; MARGIN: 0px; WIDTH: 155px; = BORDER-TOP: 0px; BORDER-RIGHT: 0px } #sectiontabs LI UL LI A { TEXT-ALIGN: left; PADDING-BOTTOM: 2px; BACKGROUND-COLOR: #ddd; = PADDING-LEFT: 5px; WIDTH: 145px; PADDING-RIGHT: 5px; COLOR: #009; = TEXT-DECORATION: none; PADDING-TOP: 2px } #sectiontabs LI UL LI A:hover { BACKGROUND-COLOR: #fff; COLOR: #900 } #sectiontabs LI:hover UL { LEFT: auto } #sectiontabs LI.sfhover UL { LEFT: auto } *:first-child + HTML #sectiontabs LI:hover UL { POSITION: static } #sectiontabs LI.sfhover UL { POSITION: static } #tablist { BORDER-BOTTOM: #999 1px solid; PADDING-BOTTOM: 22px; MARGIN: 6px 0px = 0px } #tablist UL { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-TOP: 0px } #tablist LI { PADDING-BOTTOM: 0px; LIST-STYLE-TYPE: none; MARGIN: 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; DISPLAY: inline; PADDING-TOP: 0px } #tablist A { BORDER-BOTTOM: #999 1px solid; BORDER-LEFT: #999 1px solid; = PADDING-BOTTOM: 2px; LINE-HEIGHT: 17px; PADDING-LEFT: 10px; = PADDING-RIGHT: 10px; BACKGROUND: #eee; FLOAT: left; COLOR: #009; = FONT-SIZE: 13px; BORDER-TOP: #999 1px solid; FONT-WEIGHT: bold; = MARGIN-RIGHT: 8px; BORDER-RIGHT: #999 1px solid; TEXT-DECORATION: none; = PADDING-TOP: 2px } #tablist A:hover { BACKGROUND: #fff; COLOR: #900 } #tablist LI A.activetab { BORDER-BOTTOM: #fff 1px solid; BACKGROUND: #fff; COLOR: #900 } #tablist UL A:hover { BACKGROUND: #fff; COLOR: #900 !important } #tabcontainer { BORDER-BOTTOM: #999 1px solid; BORDER-LEFT: #999 1px solid; = PADDING-BOTTOM: 10px; MARGIN: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: = 10px; BACKGROUND: #fff; CLEAR: both; BORDER-TOP: medium none; = BORDER-RIGHT: #999 1px solid; PADDING-TOP: 10px } H1 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; COLOR: #900; FONT-SIZE: 18px; PADDING-TOP: 0px } H1.moreleft { MARGIN-BOTTOM: -3px; FLOAT: left; COLOR: #000 } H1.story { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FONT-SIZE: = 20px; PADDING-TOP: 10px } H2 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; COLOR: #900; FONT-SIZE: 16px; PADDING-TOP: 0px } H2.block { COLOR: #000 } H2.videos { PADDING-TOP: 6px } H2.headleft { FLOAT: left; COLOR: #000; PADDING-TOP: 5px } DIV.headright { TEXT-ALIGN: right; PADDING-TOP: 7px } DIV.moreright { TEXT-ALIGN: right; MARGIN-BOTTOM: -3px; PADDING-TOP: 5px } DIV.nextedition { TEXT-ALIGN: right; MARGIN-TOP: -3px } DIV.otherleft { PADDING-BOTTOM: 15px; MARGIN: -15px 0px 0px; PADDING-LEFT: 0px; WIDTH: = 339px; PADDING-RIGHT: 10px; FLOAT: left; PADDING-TOP: 0px } DIV.otherright { MARGIN: 5px 0px 0px; WIDTH: 329px; FLOAT: left } H3 { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; COLOR: #000; FONT-SIZE: 14px; PADDING-TOP: 0px } HR { BORDER-BOTTOM: 0px; BORDER-LEFT: 0px; BACKGROUND: #000; HEIGHT: 0px; = BORDER-TOP: #000 1px solid; BORDER-RIGHT: 0px } A { COLOR: #009; TEXT-DECORATION: none } A:hover { TEXT-DECORATION: underline } A.red { COLOR: #900; TEXT-DECORATION: none } A.red:hover { TEXT-DECORATION: underline } A.blue { COLOR: #009; TEXT-DECORATION: none } A.blue:visited { COLOR: #006 } A.blue:hover { TEXT-DECORATION: underline } A.black { COLOR: #000; TEXT-DECORATION: none } A.black:hover { TEXT-DECORATION: underline } A.gray { COLOR: #666; TEXT-DECORATION: none } A.gray:hover { TEXT-DECORATION: underline } IMG.floatLeft { MARGIN: 2px 5px 5px 0px; FLOAT: left } .left { FLOAT: left } .right { FLOAT: right } .alignRight { TEXT-ALIGN: right } .clear { CLEAR: both } #topstories { POSITION: relative; PADDING-BOTTOM: 0px; MARGIN: 0px 0px 10px; = PADDING-LEFT: 0px; PADDING-RIGHT: 0px; HEIGHT: 215px; OVERFLOW: visible; = PADDING-TOP: 0px } DIV.panel { DISPLAY: none } #topstories DIV.storyphoto { MARGIN: 2px 10px 2px 0px; WIDTH: 100px; FLOAT: left; MAX-HEIGHT: 150px; = OVERFLOW: hidden } #topstories DIV.storyblurb { WIDTH: 230px; FLOAT: left } DIV.moreon { MARGIN: 10px 5px 0px 0px; WIDTH: 70px; FLOAT: left } DIV.moreon UL { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 10px 15px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; LIST-STYLE-IMAGE: url(/images/bullet_black.gif); = PADDING-TOP: 0px } DIV.moretopics { MARGIN: 10px 10px 0px 0px; WIDTH: 249px; FLOAT: left } #mainstories { POSITION: relative; PADDING-BOTTOM: 0px; MARGIN: 5px 0px; PADDING-LEFT: = 0px; PADDING-RIGHT: 0px; HEIGHT: 160px; OVERFLOW: visible; PADDING-TOP: = 0px } #mainstories DIV.storyphoto { MARGIN: 2px 10px 2px 0px; WIDTH: 75px; FLOAT: left; MAX-HEIGHT: 125px; = OVERFLOW: hidden } #mainstories DIV.storyblurb { WIDTH: 190px; FLOAT: left } #story1 { DISPLAY: block } DIV.firststory { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 5px } DIV.secondstory { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; CLEAR: = both; PADDING-TOP: 5px } #videos { PADDING-TOP: 3px } #video { PADDING-BOTTOM: 10px } #googlesearch TABLE { MARGIN: 0px auto; PADDING-TOP: 10px } #googlesearch TABLE TABLE { MARGIN: 0px } BLOCKQUOTE { PADDING-BOTTOM: 5px; MARGIN: 0px; PADDING-LEFT: 10px; PADDING-RIGHT: = 10px; PADDING-TOP: 5px } #misc { DISPLAY: none } .amazon { MARGIN: 10px 0px; CLEAR: both } FORM { PADDING-BOTTOM: 0px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; PADDING-TOP: 0px } #story { WIDTH: 365px; FLOAT: left } #first { MARGIN-TOP: 0px; MARGIN-BOTTOM: -2px; FONT-SIZE: medium; PADDING-TOP: = 0px } SPAN.date { FONT-STYLE: italic; COLOR: #666 } #seealso { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; WIDTH: 140px; PADDING-RIGHT: = 10px; FLOAT: left; PADDING-TOP: 2px } #seealso DIV { PADDING-TOP: 10px } #seealso UL { PADDING-BOTTOM: 0px; MARGIN: 0px 0px 0px 20px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; PADDING-TOP: 0px } #seealso UL LI { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 0px } #photo { MARGIN: 5px 0px } P { PADDING-BOTTOM: 5px; MARGIN: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: = 0px; FONT-SIZE: 13px; PADDING-TOP: 5px } #related { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 300px; PADDING-RIGHT: = 0px; FLOAT: right; PADDING-TOP: 0px } #relatedstories DIV { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 10px } #related_articles DIV { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 5px } #morenewsleft { WIDTH: 260px; FLOAT: left } #morenewsright { WIDTH: 230px; FLOAT: right } #rssbox { BORDER-BOTTOM: #999 1px solid; BORDER-LEFT: #999 1px solid; = PADDING-BOTTOM: 10px; MARGIN: 8px 0px 10px 10px; PADDING-LEFT: 10px; = WIDTH: 200px; PADDING-RIGHT: 10px; BORDER-TOP: #999 1px solid; = BORDER-RIGHT: #999 1px solid; PADDING-TOP: 10px } #article_note { BORDER-BOTTOM: #999 1px solid; BORDER-LEFT: #999 1px solid; = PADDING-BOTTOM: 10px; MARGIN: 10px 0px; PADDING-LEFT: 10px; = PADDING-RIGHT: 10px; BORDER-TOP: #999 1px solid; BORDER-RIGHT: #999 1px = solid; PADDING-TOP: 10px } #book_details { MARGIN: 0px 0px 10px } #moreheadlines { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: = left; PADDING-TOP: 2px } DIV.edition { DISPLAY: none } DIV.morepanel { DISPLAY: none } #panel1 { DISPLAY: block } #scroll { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = PADDING-TOP: 2px } DIV.scroll_topics { WIDTH: 150px; FLOAT: left } DIV.scroll_headlines { MARGIN: 0px 0px 12px 10px; WIDTH: 295px; FLOAT: left } DIV.section_topics { WIDTH: 150px; FLOAT: left } DIV.section_headlines { MARGIN: 0px 10px 12px; WIDTH: 324px; FLOAT: left } DIV.search_topics { WIDTH: 150px; FLOAT: left } DIV.search_headlines { MARGIN: 0px 0px 12px 10px; WIDTH: 295px; FLOAT: left } #citationbox { BORDER-BOTTOM: #999 1px solid; BORDER-LEFT: #999 1px solid; = PADDING-BOTTOM: 10px; MARGIN: 10px 0px; PADDING-LEFT: 10px; = PADDING-RIGHT: 10px; BORDER-TOP: #999 1px solid; BORDER-RIGHT: #999 1px = solid; PADDING-TOP: 10px } #citationformat { WIDTH: 55px; FLOAT: left } #citationtext { MARGIN: 0px 0px 0px 65px } #bottomsearch { BORDER-BOTTOM: medium none; BORDER-LEFT: medium none; PADDING-BOTTOM: = 0px; MARGIN: 5px 0px 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; = BORDER-TOP: medium none; BORDER-RIGHT: medium none; PADDING-TOP: 0px } #googleside { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; WIDTH: 175px; PADDING-RIGHT: = 0px; FONT-SIZE: 13px; PADDING-TOP: 10px } #googleside DIV { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; OVERFLOW: = hidden; PADDING-TOP: 5px } #googleside DIV.left { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: = left; FONT-SIZE: 11px; PADDING-TOP: 0px } #googleside DIV.right { TEXT-ALIGN: right; PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-SIZE: 11px; PADDING-TOP: 0px } #googleside DIV.clear { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; CLEAR: = both; PADDING-TOP: 0px } #googlephoto { PADDING-BOTTOM: 15px; PADDING-LEFT: 0px; WIDTH: 300px; PADDING-RIGHT: = 0px; FONT-SIZE: 13px; PADDING-TOP: 0px } #googlephoto DIV { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; OVERFLOW: = hidden; PADDING-TOP: 5px } #googlephoto DIV.left { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: = left; FONT-SIZE: 11px; PADDING-TOP: 0px } #googlephoto DIV.right { TEXT-ALIGN: right; PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-SIZE: 11px; PADDING-TOP: 0px } #googlephoto DIV.clear { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; CLEAR: = both; PADDING-TOP: 0px } #googlerelated { PADDING-BOTTOM: 15px; PADDING-LEFT: 0px; WIDTH: 300px; PADDING-RIGHT: = 0px; FONT-SIZE: 13px; PADDING-TOP: 10px } #googlerelated DIV { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; OVERFLOW: = hidden; PADDING-TOP: 5px } #googlerelated DIV.left { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: = left; FONT-SIZE: 11px; PADDING-TOP: 0px } #googlerelated DIV.right { TEXT-ALIGN: right; PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-SIZE: 11px; PADDING-TOP: 0px } #googlerelated DIV.clear { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; CLEAR: = both; PADDING-TOP: 0px } #googlestory { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; WIDTH: 358px; PADDING-RIGHT: = 0px; FONT-SIZE: 13px; PADDING-TOP: 10px } #googlestory DIV { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; OVERFLOW: = hidden; PADDING-TOP: 5px } #googlestory DIV.left { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: = left; FONT-SIZE: 11px; PADDING-TOP: 0px } #googlestory DIV.right { TEXT-ALIGN: right; PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-SIZE: 11px; PADDING-TOP: 0px } #googlestory DIV.clear { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; CLEAR: = both; PADDING-TOP: 0px } #googleleft { MARGIN: 5px 0px 0px; WIDTH: 138px; FONT-SIZE: 13px } #googleleft DIV { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; OVERFLOW: = hidden; PADDING-TOP: 5px } #googleleft DIV.left { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: = left; FONT-SIZE: 11px; PADDING-TOP: 0px } #googleleft DIV.right { TEXT-ALIGN: right; PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-SIZE: 11px; PADDING-TOP: 0px } #googleleft DIV.clear { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; CLEAR: = both; PADDING-TOP: 0px } #googlesearch { PADDING-BOTTOM: 10px; PADDING-LEFT: 10px; WIDTH: 175px; PADDING-RIGHT: = 0px; FLOAT: right; FONT-SIZE: 13px; OVERFLOW: hidden; PADDING-TOP: 10px } #googlesearch DIV { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; OVERFLOW: = hidden; PADDING-TOP: 5px } #googlesearch DIV.left { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: = left; FONT-SIZE: 11px; PADDING-TOP: 0px } #googlesearch DIV.right { TEXT-ALIGN: right; PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-SIZE: 11px; PADDING-TOP: 0px } #googlesearch DIV.clear { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; CLEAR: = both; PADDING-TOP: 0px } #googlehome { PADDING-BOTTOM: 10px; PADDING-LEFT: 0px; WIDTH: 180px; PADDING-RIGHT: = 10px; FONT-SIZE: 13px; OVERFLOW: hidden; PADDING-TOP: 5px } #googlehome DIV { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; OVERFLOW: = hidden; PADDING-TOP: 5px } #googlehome DIV.left { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: = left; FONT-SIZE: 11px; PADDING-TOP: 0px } #googlehome DIV.right { TEXT-ALIGN: right; PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-SIZE: 11px; PADDING-TOP: 0px } #googlehome DIV.clear { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; CLEAR: = both; PADDING-TOP: 0px } #googletop { MARGIN: 0px 0px 10px; FONT-SIZE: 13px } #googletop DIV { OVERFLOW: hidden } #googletop DIV.left { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: = left; FONT-SIZE: 11px; PADDING-TOP: 0px } #googletop DIV.right { TEXT-ALIGN: right; PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; = PADDING-RIGHT: 0px; FONT-SIZE: 11px; PADDING-TOP: 0px } #googletop DIV.clear { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; CLEAR: = both; PADDING-TOP: 0px } #googletop DIV.col1 { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; WIDTH: 164px; PADDING-RIGHT: = 5px; FLOAT: left; PADDING-TOP: 5px } #googletop DIV.col2 { PADDING-BOTTOM: 5px; PADDING-LEFT: 5px; WIDTH: 164px; PADDING-RIGHT: = 5px; FLOAT: left; PADDING-TOP: 5px } #googletop DIV.col3 { PADDING-BOTTOM: 5px; PADDING-LEFT: 5px; WIDTH: 164px; PADDING-RIGHT: = 0px; FLOAT: right; PADDING-TOP: 5px } #googleend { MARGIN: 0px 0px 10px; FONT-SIZE: 13px } #googleend DIV { OVERFLOW: hidden } #googleend DIV.left { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; FLOAT: = left; FONT-SIZE: 11px; PADDING-TOP: 0px } #googleend DIV.right { TEXT-ALIGN: 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} #googlebottom DIV.clear { PADDING-BOTTOM: 0px; PADDING-LEFT: 0px; PADDING-RIGHT: 0px; CLEAR: = both; PADDING-TOP: 0px } #googlebottom DIV.col1 { PADDING-BOTTOM: 5px; PADDING-LEFT: 0px; WIDTH: 210px; PADDING-RIGHT: = 5px; FLOAT: left; PADDING-TOP: 5px } #googlebottom DIV.col2 { PADDING-BOTTOM: 5px; PADDING-LEFT: 5px; WIDTH: 220px; PADDING-RIGHT: = 5px; FLOAT: left; PADDING-TOP: 5px } #googlebottom DIV.col3 { PADDING-BOTTOM: 5px; PADDING-LEFT: 5px; WIDTH: 210px; PADDING-RIGHT: = 0px; FLOAT: right; PADDING-TOP: 5px } #share_form { Z-INDEX: 999; BORDER-BOTTOM: #999 1px solid; POSITION: absolute; = BORDER-LEFT: #999 1px solid; WIDTH: 300px; DISPLAY: none; BACKGROUND: = #eee; BORDER-TOP: #999 1px solid; BORDER-RIGHT: #999 1px solid } #share_title { MARGIN: 5px; WIDTH: 60%; FLOAT: left } #share_close { FONT-STYLE: italic; MARGIN: 5px; FLOAT: right } #share_close A { COLOR: #009; TEXT-DECORATION: none } #share_close A:hover { COLOR: #900; TEXT-DECORATION: none } #share_form DIV.clear { 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