MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C92710.74AC78F0" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01C92710.74AC78F0 Content-Location: file:///C:/E31C9A45/Newsletter_5_October_20081.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" 5 October 2008

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5 October 2008

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22 U.S. contracts for “Covered Countermeasures” against anthrax listed = in HHS PREP Act Declaration

&nb= sp;

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On October 1, 2008 the U.S. Department of Health and Human Services (HHS) published on their website www.hhs.gov a “Declaration under the Public Readiness and Emergency Preparedness Act” (“PR= EP Act”) that was summarized as:

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“Declaration pursuant to section 319F-3 of the Public Health Service Act (42 U.S.C. 247d= -6d) to provide targeted liability protections for anthrax countermeasures based= on a credible risk that the threat of exposure to Bacillus anthracis and the resulting disease constitutes a public health emergency”. =

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Importantly, this declaration does NOT mean that there is any known imminent threat of= an anthrax attack.

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Previously, Secre= tary Ridge made a determination on January 20, 2004 that “anthrax presents= a material threat against the United States population sufficient to affect national security.”  On September 22, 2006 Secretary of the U.S. Department of Homeland Security (D= HS) Michael Chertoff “made a determination under the same provision that “multidrug resistant Bacillus anthracis presents such a threat” (cited in a footnote on page 1 of 2 in&nbs= p; the  September 23, 2008 memorandum pertaining to anthrax from Secretary Chertoff to HHS Secretary Michael Leavitt posted on the DHS website at: www.dhs.gov/xlibrary/assets/ofsec_signed_determination092308.pdf)=

 

The HHS Declarati= on on October 1st that focuses on “targeted liability protect= ions for anthrax countermeasures” specifically cites “Covered Countermeasures”. These include 22 specific contracts listed in Appen= dix 1 of the HHS document that can be found on the HHS website at: www.hhs.gov/disasters/emergency/manmadedisasters/biot= erorism/prepact-081001.html

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Each of these 22 = U.S. government contracts listed in Appendix 1 include the “Covered Countermeasure and the “Manufacturer”.  These countermeasures can be divid= ed into three categories:

= A.&n= bsp;      Anthrax antitoxin(s) (antibody)

= B.&n= bsp;      Anthrax Vaccine

= C.&n= bsp;     Antibiotic= s

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For example, Anth= rax antitoxin(s)-antibodies listed in Appendix 1 include: Anthrax Immune Globul= in (AIG) made both by Cangene and Emergent Biosolutions, and manufacturer-spec= ific Anthrax monoclonal antibody made by HGS, Elusys, Pharma= thene.

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Anthrax vaccine includes both the Biothrax (Anthrax Vaccine, Adsorbed, AVA) manufactured by Emergent Biodefense Operations and BioPort (Emergent Biosolutions), as well= as a newer generation of anthrax vaccine “recombinant protective antigen (rPA)” by Avencia (Pharmathene).

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Antibiotics inclu= de: doxycycline, levofloxacin, ciprofloxacin, penicillin, amoxicillin, rifampin, vancomycin, and clindamycin (made by multiple specific manufacturers listed= in Appendix 1).

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This is a notewor= thy reference document that addresses a long-recognized issue regarding liabili= ty for anthrax countermeasures. The list of “Covered CountermeasuresR= 21; in Appendix 1 is of value to emergency planners as well as potentially to individual clinicians who appreciate the threat of another anthrax attack, especially with a multidrug-resistant Bacillus anthracis.

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Daniel R. Lucey, = MD, MPH

EROne Institutes, Dept. of Emergency Medicine

Washington Hospit= al Center

Adjunct Professor= of Microbiology and Immunology

Georgetown University Medical Center, Washington, D.C.

Website for this posting: www.BePast.org

e-mail:DRL23@Geor= getown.edu

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